4.7 Review

Neuroprotective Mechanisms of Ginsenoside Rb1 in Central Nervous System Diseases

Related references

Note: Only part of the references are listed.
Article Plant Sciences

Ginsenoside Rb1 prevents lipopolysaccharide-induced depressive-like behavior by inhibiting inflammation and neural dysfunction and F2 elicits a novel antidepressant-like effect: A metabolite-based network pharmacology study

Wenyi Liang et al.

Summary: The study showed that Ginsenoside Rb1 has antidepressant effects by inhibiting inflammation and regulating serotonin levels, while its metabolite F2 has a more significant effect against depression. This research provides important clues for Rb1 and F2 as potential drugs for treating inflammation-induced depression.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Review Chemistry, Medicinal

Ginsenosides in central nervous system diseases: Pharmacological actions, mechanisms, and therapeutics

Jing Lu et al.

Summary: This review summarizes the potential pathways by which ginsenosides affect the pathogenesis of central nervous system diseases (CNSDs), including antioxidant effects, anti-inflammatory effects, anti-apoptotic effects, and nerve protection. Ginsenosides have been shown to prevent various CNSDs, such as neurodegenerative diseases, cerebral ischemia injury, and depression.

PHYTOTHERAPY RESEARCH (2022)

Review Geriatrics & Gerontology

Panax ginseng and aging related disorders: A systematic review

Barbara de Oliveira Zanuso et al.

Summary: The aging process can lead to various disorders and diseases, and Panax ginseng has shown therapeutic benefits in managing these conditions. The chemical constituents in ginseng have anti-inflammatory, antioxidant, and neuroprotective effects. Using ginseng as a complementary treatment can improve the quality of life for patients with chronic diseases related to aging.

EXPERIMENTAL GERONTOLOGY (2022)

Article Oncology

NRF2 and Key Transcriptional Targets in Melanoma Redox Manipulation

Evan L. Carpenter et al.

Summary: Melanocytes are pigment-producing cells in the skin that protect against UV radiation by synthesizing melanin and distributing it to adjacent cells. They face oxidative stress and utilize antioxidant systems, regulated by NRF2, to prevent cancer formation. However, melanomas hijack these systems for uncontrolled growth and metastasis, presenting a challenge for treatment.

CANCERS (2022)

Article Cell Biology

Ginsenoside Rb1 attenuates microglia activation to improve spinal cord injury via microRNA-130b-5p/TLR4/NF-κB axis

Dan Wang et al.

Summary: The study revealed that GRb1 alleviated spinal cord injury by reducing neuronal injury and inflammation through regulation of the miR-130b-5p/TLR4/NF-kappa B axis. Additionally, GRb1 also attenuated the damage of activated microglia to neurons.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Article Clinical Neurology

Distinct effects of beta-amyloid and tau on cortical thickness in cognitively healthy older adults

Theresa M. Harrison et al.

Summary: The study found that tau biomarkers have a stronger relationship with cortical thickness and memory, while Aβ has a weaker relationship with cortical thickness; FTP strongly negatively predicted cortical thickness regardless of PiB status; this research helps explain the complex relationship between pathology and neurodegeneration.

ALZHEIMERS & DEMENTIA (2021)

Article Integrative & Complementary Medicine

Ginsenoside Rb1 Protects Human Umbilical Vein Endothelial Cells against High Glucose-Induced Mitochondria-Related Apoptosis through Activating SIRT3 Signalling Pathway

Ke Shi-ye et al.

Summary: The results showed that Rb1 can protect HUVECs from high glucose-induced apoptosis by promoting mitochondrial function and suppressing oxidative stress through the SIRT3 signaling pathway.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2021)

Article Biochemistry & Molecular Biology

C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease

Yiyuan Xia et al.

Summary: C/EBP beta serves as a crucial transcription factor for temporally regulating APOE gene expression, modulating the role of ApoE4 in Alzheimer's disease pathogenesis. It promotes ApoE expression in the brain and accelerates AD pathologies.

MOLECULAR PSYCHIATRY (2021)

Article Neurosciences

Ginsenoside Rb1 exerts antidepressant-like effects via suppression inflammation and activation of AKT pathway

Ying Guo et al.

Summary: Ginsenoside Rb1 has antidepressant effects in mice subjected to chronic restraint stress, possibly through inhibiting inflammation responses and protecting microglia cells.

NEUROSCIENCE LETTERS (2021)

Article Pharmacology & Pharmacy

Ginsenoside Rb1 protected PC12 cells from Aβ25-35-induced cytotoxicity via PPARγ activation and cholesterol reduction

Ke Changhong et al.

Summary: The study found that ginsenoside Rb1 can protect cells from Aβ-induced cytotoxicity, acting as an agonist of PPARγ to reduce cholesterol levels in AD model cells. Lowering cholesterol levels reduced Aβ-induced cytotoxicity.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Article Behavioral Sciences

Protective effect of ginsenoside Rb1 against chronic restraint stress (CRS)-induced memory impairments in rats

Ning Jiang et al.

Summary: The study showed that Rb1 rescued cognitive deficits induced by CRS partially through antagonizing oxidative stress and apoptosis, improving synaptic plasticity, and restoring the BDNF/TrkB signaling pathway.

BEHAVIOURAL BRAIN RESEARCH (2021)

Article Pharmacology & Pharmacy

Ginsenoside Rb1 Produces Antidepressant-Like Effects in a Chronic Social Defeat Stress Model of Depression Through the BDNF-Trkb Signaling Pathway

Ning Jiang et al.

Summary: The study demonstrated that Ginsenoside Rb1 can significantly reverse depressive-like behaviors induced by chronic social defeat stress through enhancing the BDNF signaling cascade and promoting hippocampal neurogenesis.

FRONTIERS IN PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Ginsenoside Compound K Promotes Proliferation, Migration and Differentiation of Schwann Cells via the Activation of MEK/ERK1/2 and PI3K/AKT Pathways

Hao Wang et al.

Summary: This study demonstrates that ginsenoside compound K can promote the proliferation and migration of Schwann cells, as well as induce the expression of myelin-associated proteins. Furthermore, CK exerts its beneficial effects by activating the MEK/ERK1/2 and PI3K/AKT pathways.

NEUROCHEMICAL RESEARCH (2021)

Article Environmental Sciences

Ginsenoside Rb1 protects from Staphylococcus aureus-induced oxidative damage and apoptosis through endoplasmic reticulum-stress and death receptor-mediated pathways

Aftab Shaukat et al.

Summary: The study demonstrated that Rb1 could protect mice from S. aureus-induced ALI by regulating ER stress and death receptor-mediated pathways. The findings provide insights into the preventive mechanism of Rb1 in ALI and support its therapeutic application.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Immunology

Ginsenoside Rb1 induces a pro-neurogenic microglial phenotype via PPARγ activation in male mice exposed to chronic mild stress

Lijuan Zhang et al.

Summary: The study showed that GRb1 alleviated depressive-like behaviors in male mice exposed to chronic mild stress mainly through the activation of PPAR gamma-mediated pro-neurogenic phenotype of microglia and enhancement of adult hippocampus neurogenesis.

JOURNAL OF NEUROINFLAMMATION (2021)

Article Geriatrics & Gerontology

Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology

David K. Simon et al.

CLINICS IN GERIATRIC MEDICINE (2020)

Article Biotechnology & Applied Microbiology

Ginsenoside Rb1 Improves Cognitive Impairment Induced by Insulin Resistance through Cdk5/p35-NMDAR-IDE Pathway

Ranyao Yang et al.

BIOMED RESEARCH INTERNATIONAL (2020)

Article Biochemistry & Molecular Biology

Ginsenoside Rb1 ameliorates autophagy via the AMPK/mTOR pathway in renal tubular epithelial cells in vitro and in vivo

Xianghua Liu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Review Clinical Neurology

Circuit Mechanisms of Reward, Anhedonia, and Depression

Anna Hoflich et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2019)

Review Biochemistry & Molecular Biology

α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis

Surabhi Mehra et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2019)

Article Biochemistry & Molecular Biology

Neuroprotective Effects of Ginsenosides against Cerebral Ischemia

Zhekang Cheng et al.

MOLECULES (2019)

Review Biochemistry & Molecular Biology

Chemical Structures and Pharmacological Profiles of Ginseng Saponins

Ze-Yu Shi et al.

MOLECULES (2019)

Article Orthopedics

Effects of ginsenoside Rb1 on spinal cord ischemia-reperfusion injury in rats

Jin-tao Ye et al.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2019)

Review Cell & Tissue Engineering

Microenvironment Imbalance of Spinal Cord Injury

Baoyou Fan et al.

CELL TRANSPLANTATION (2018)

Article Cell Biology

Ginsenoside Rb1 Protects the Brain from Damage Induced by Epileptic Seizure via Nrf2/ARE Signaling

Yunbo Shi et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Article Integrative & Complementary Medicine

Effect of Qingxin Kaiqiao Fang on Hippocampus mRNA Expression of the Inflammation-Related Genes IL-1β, GFAP, and Aβ in an Alzheimer's Disease Rat Model

Dan-Dan Mao et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)

Article Medicine, Research & Experimental

Effects of ginsenoside Rb1 on oxidative stress injury in rat spinal cords by regulating the eNOS/Nrf2/HO-1 signaling pathway

Xinwei Liu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2018)

Review Geriatrics & Gerontology

Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease

Xian-Si Zeng et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

Review Pharmacology & Pharmacy

Thioredoxin as a Therapeutic Target in Cerebral Ischemia

Xian-Si Zeng et al.

CURRENT PHARMACEUTICAL DESIGN (2018)

Article Medicine, Research & Experimental

Ginsenoside Rb1 administration attenuates focal cerebral ischemic reperfusion injury through inhibition of HMGB1 and inflammation signals

Anxin Liu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2018)

Article Pharmacology & Pharmacy

The Effects of Ginsenoside Compound K Against Epilepsy by Enhancing the γ-Aminobutyric Acid Signaling Pathway

Xiangchang Zeng et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Chemistry, Medicinal

Research of Panax spp. in Kunming Institute of Botany, CAS

Yi-Jun Qiao et al.

NATURAL PRODUCTS AND BIOPROSPECTING (2018)

Article Cell Biology

Inhibition of Autophagy is Involved in the Protective Effects of Ginsenoside Rb1 on Spinal Cord Injury

Peng Wang et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2018)

Article Neurosciences

Autophagy Inhibition Favors Survival of Rubrospinal Neurons After Spinal Cord Hemisection

Elisa Bisicchia et al.

MOLECULAR NEUROBIOLOGY (2017)

Article Geriatrics & Gerontology

Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease

Melissa K. Edler et al.

NEUROBIOLOGY OF AGING (2017)

Review Clinical Neurology

Pathogenic mechanisms following ischemic stroke

Seyed Esmaeil Khoshnam et al.

NEUROLOGICAL SCIENCES (2017)

Article Clinical Neurology

Traumatic Spinal Cord Injury-Repair and Regeneration

Christopher S. Ahuja et al.

NEUROSURGERY (2017)

Review Clinical Neurology

Genetic Forms of Parkinson's Disease

Christine Y. Kim et al.

SEMINARS IN NEUROLOGY (2017)

Review Neurosciences

The MPTP Story

J. William Langston

JOURNAL OF PARKINSONS DISEASE (2017)

Article Medicine, General & Internal

Traumatic spinal cord injury

Christopher S. Ahuja et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Article Pathology

Enhanced Tau Aggregation in the Presence of Amyloid β

Rachel E. Bennett et al.

AMERICAN JOURNAL OF PATHOLOGY (2017)

Review Orthopedics

Spinal Cord Injury and Related Clinical Trials

Young-Hoon Kim et al.

CLINICS IN ORTHOPEDIC SURGERY (2017)

Article Cell Biology

The expression of thioredoxin-1 in acute epinephrine stressed mice

Jin-Jing Jia et al.

CELL STRESS & CHAPERONES (2016)

Review Neurosciences

PATHOGENESIS OF DEPRESSION: INSIGHTS FROM HUMAN AND RODENT STUDIES

C. Menard et al.

NEUROSCIENCE (2016)

Article Hematology

A possible new role for Aβ in vascular and inflammatory dysfunction in Alzheimer's disease

Daria Zamolodchikov et al.

THROMBOSIS RESEARCH (2016)

Review Biotechnology & Applied Microbiology

Biosynthesis and biotechnological production of ginsenosides

Yu-Jin Kim et al.

BIOTECHNOLOGY ADVANCES (2015)

Article Biochemical Research Methods

Protective effects of ginsenosides Rg1 and Rb1 on an Alzheimer's disease mouse model: A metabolomics study

Naijing Li et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2015)

Article Pharmacology & Pharmacy

Comparative analysis of the neuroprotective effects of ginsenosides Rg1 and Rb1 extracted from Panax notoginseng against cerebral ischemia

Xian-Si Zeng et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2014)

Article Environmental Sciences

Effects of ginsenoside Rb1 on the stress-induced changes of BDNF and HSP70 expression in rat hippocampus

Mia Kim et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2014)

Article Biochemistry & Molecular Biology

The role of thioredoxin-1 in suppression of endoplasmic reticulum stress in Parkinson disease

Xian-Si Zeng et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

Review Biochemistry & Molecular Biology

Saponins in the genus Panax L. (Araliaceae): A systematic review of their chemical diversity

Wen-zhi Yang et al.

PHYTOCHEMISTRY (2014)

Article Integrative & Complementary Medicine

Effect of Panax notoginseng in Patients with Multiple Fractured Ribs and Pulmonary Contusions Caused by the 2008 Wenchuan Earthquake

Ma Tianhong et al.

FORSCHENDE KOMPLEMENTARMEDIZIN (2014)

Review Plant Sciences

The world ginseng market and the ginseng (Korea)

In-Ho Baeg et al.

JOURNAL OF GINSENG RESEARCH (2013)

Article

Brain-Immune Interactions and Ischemic Stroke

Costantino Iadecola

ARCHIVES OF NEUROLOGY (2012)

Review Pharmacology & Pharmacy

Ginsenoside Rb1 Directly Scavenges Hydroxyl Radical and Hypochlorous Acid

Jian-Ming Lu et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

Article Biochemistry & Molecular Biology

DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway

Joo-Young Im et al.

HUMAN MOLECULAR GENETICS (2012)

Article Cardiac & Cardiovascular Systems

Current Status of Endovascular Stroke Treatment

Philip M. Meyers et al.

CIRCULATION (2011)

Review Biochemistry & Molecular Biology

Isolation and analysis of ginseng: advances and challenges

Lian-Wen Qi et al.

NATURAL PRODUCT REPORTS (2011)

Article Oncology

Ginsenoside Rb1 protects PC12 cells against β-amyloid-induced cell injury

Xia Xie et al.

MOLECULAR MEDICINE REPORTS (2010)

Article Neurosciences

Ginsenosides Protect Striatal Neurons in a Cellular Model of Huntington's Disease

Jun Wu et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2009)

Review Chemistry, Multidisciplinary

Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A!Meyer

Kwang-tae Choi

ACTA PHARMACOLOGICA SINICA (2008)

Review Pharmacology & Pharmacy

Pharmacological activity of sanchi ginseng (Panax notoginseng)

T. B. Ng

JOURNAL OF PHARMACY AND PHARMACOLOGY (2006)

Review Neurosciences

Mood disorders in the medically ill: Scientific review and recommendations

DL Evans et al.

BIOLOGICAL PSYCHIATRY (2005)

Review Neurosciences

Microglia and Alzheimer's disease pathogenesis

WJ Streit

JOURNAL OF NEUROSCIENCE RESEARCH (2004)

Article Biochemistry & Molecular Biology

Overexpression of nicastrin increases Aβ production

MP Murphy et al.

FASEB JOURNAL (2003)

Review Medicine, General & Internal

Spinal-cord injury

JW McDonald et al.

LANCET (2002)

Article Medicine, General & Internal

Brief introduction of Panax ginseng CA Meyer

TK Yun

JOURNAL OF KOREAN MEDICAL SCIENCE (2001)