4.7 Article

GPX4 Plays a Crucial Role in Fuzheng Kang'ai Decoction-Induced Non-Small Cell Lung Cancer Cell Ferroptosis

Related references

Note: Only part of the references are listed.
Article Plant Sciences

Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer

Jian-Shu Lou et al.

Summary: The study found that ginkgetin derived from Ginkgo biloba leaves enhances DDP-induced cytotoxicity in NSCLC cells through inducing ferroptosis. The results indicate that, in addition to enhancing DDP-induced cytotoxicity, ginkgetin can disrupt redox homeostasis in DDP-treated cells and enhance apoptosis.

PHYTOMEDICINE (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Multidisciplinary Sciences

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Yilei Zhang et al.

Summary: Cystine uptake promotes GPX4 synthesis by activating mTORC1, sensitizing cancer cells to ferroptosis. Inhibiting mTORC1 decreases GPX4 protein levels and enhances the effectiveness of ferroptosis inducers in cancer treatment.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

xCT-Driven Expression of GPX4 Determines Sensitivity of Breast Cancer Cells to Ferroptosis Inducers

Namgyu Lee et al.

Summary: The study revealed that breast cancer cells are more sensitive to inducers of ferroptosis such as Erastin and Rsl-3 due to their dependency on the xCT/GPX4 axis. This finding provides a strategic basis for targeting the anti-ferroptotic machinery of breast cancer cells based on their xCT status.

ANTIOXIDANTS (2021)

Review Oncology

Frontiers of ctDNA, targeted therapies, and immunotherapy in non-small-cell lung cancer

Chennianci Zhu et al.

TRANSLATIONAL LUNG CANCER RESEARCH (2020)

Review Biochemistry & Molecular Biology

Role of GPX4 in ferroptosis and its pharmacological implication

Tobias M. Seibt et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Review Physiology

Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review

Pengxu Lei et al.

FRONTIERS IN PHYSIOLOGY (2019)

Review Medicine, General & Internal

Systemic Therapy for Locally Advanced and Metastatic Non-Small Cell Lung Cancer A Review

Kathryn C. Arbour et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Review Integrative & Complementary Medicine

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Hua Luo et al.

CHINESE MEDICINE (2019)

Article Integrative & Complementary Medicine

Application of Traditional Chinese Medicines as Personalized Therapy in Human Cancers

Sumei Wang et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2018)

Review Biochemistry & Molecular Biology

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

Matilde Maiorino et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Article Integrative & Complementary Medicine

Decoction of Chinese Herbal Medicine Fuzheng Kang-Ai Induces Lung Cancer Cell Apoptosis via STAT3/Bcl-2/Caspase-3 Pathway

Sumei Wang et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)

Review Pharmacology & Pharmacy

Modulating ROS to overcome multidrug resistance in cancer

Qingbin Cui et al.

DRUG RESISTANCE UPDATES (2018)

Review Pharmacology & Pharmacy

Ferroptosis Inhibition: Mechanisms and Opportunities

Jose Pedro Friedmann Angeli et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

Article Integrative & Complementary Medicine

Chinese Herbal Medicine Fuzheng Kang-Ai Decoction Inhibited Lung Cancer Cell Gro through AMPKα-Mediated Induction and Interplay of IGFBP1 d FOXO3a

Fang Zheng et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016)

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

Article Integrative & Complementary Medicine

Effect of gefitinib plus Chinese herbal medicine (CHM) in patients with advanced non-small-cell lung cancer: A retrospective case control study

Xiao-Bing Yang et al.

COMPLEMENTARY THERAPIES IN MEDICINE (2014)

Article Cell Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Jose Pedro Friedmann Angeli et al.

NATURE CELL BIOLOGY (2014)

Review Biochemistry & Molecular Biology

The oxidative stress-inducible cystine/glutamate antiporter, system xc-: cystine supplier and beyond

Marcus Conrad et al.

AMINO ACIDS (2012)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Integrative & Complementary Medicine

Treatment of Advanced Non-small Cell Lung Cancer with Extracorporeal High Frequency Thermotherapy Combined with Chinese Medicine

Wu Wan-yin et al.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2010)

Review Medicine, General & Internal

Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship

Julian R. Molina et al.

MAYO CLINIC PROCEEDINGS (2008)

Review Medicine, General & Internal

Molecular origins of cancer: Lung cancer

Roy S. Herbst et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)