4.7 Article

Liquiritin Attenuates Pathological Cardiac Hypertrophy by Activating the PKA/LKB1/AMPK Pathway

Related references

Note: Only part of the references are listed.
Article Oncology

The RING-domain E3 ubiquitin ligase RNF146 promotes cardiac hypertrophy by suppressing the LKB1/AMPK signaling pathway

Zhiyong Sheng et al.

Summary: RNF146 plays an important role in cardiac hypertrophy by suppressing the activation of the AMPK signaling pathway.

EXPERIMENTAL CELL RESEARCH (2022)

Article Biotechnology & Applied Microbiology

Protective effect of liquiritin on coronary heart disease through regulating the proliferation of human vascular smooth muscle cells via upregulation of sirtuin1

Liang Yuan et al.

Summary: This study found that liquiritin plays a protective role in coronary heart disease by regulating the proliferation and migration of hVSMCs through increasing SIRT1 expression.

BIOENGINEERED (2022)

Article Medicine, Research & Experimental

HRAS germline mutations impair LKB1/AMPK signaling and mitochondrial homeostasis in Costello syndrome models

Laetitia Dard et al.

Summary: This study analyzed the molecular determinants of Costello syndrome and found that mitochondrial proteostasis and bioenergetics play a crucial role in the pathophysiology of the disease. The study suggests that patients with Costello syndrome may benefit from treatment with mitochondrial modulators.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Article Chemistry, Multidisciplinary

Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice

Xin Zhang et al.

Summary: Matrine attenuates cardiac fibrosis by regulating RPS5/p38 signaling, showing promising potential as a therapeutic agent for treating pathological cardiac fibrosis.

ACTA PHARMACOLOGICA SINICA (2021)

Review Pharmacology & Pharmacy

Energy metabolism disorders and potential therapeutic drugs in heart failure

Yanan He et al.

Summary: Heart failure is a global public health issue caused by severe energy metabolism disorders leading to insufficient heart energy supply. Current therapies focus on symptomatic treatment by reducing heart rate and cardiac load, but there are no drugs targeting cardiac energy metabolism.

ACTA PHARMACEUTICA SINICA B (2021)

Article Cardiac & Cardiovascular Systems

Cardiac Energy Metabolism in Heart Failure

Gary D. Lopaschuk et al.

Summary: Changes in cardiac energy metabolism are complex and depend on the severity and type of heart failure, as well as the presence of common comorbidities such as obesity and type 2 diabetes. The failing heart experiences an energy deficit due to decreased mitochondrial oxidative capacity, compensated for by increased ATP production from glycolysis. Alterations in mitochondrial ATP production fuels and fatty acid oxidation contribute to the inefficiency of the failing heart, with potential therapeutic targets in energy metabolic pathways to improve cardiac function.

CIRCULATION RESEARCH (2021)

Article Pharmacology & Pharmacy

Liquiritin Attenuates Lipopolysaccharides-Induced Cardiomyocyte Injury via an AMP-Activated Protein Kinase-Dependent Signaling Pathway

Shan-Qi Mou et al.

Summary: LIQ administration attenuates LPS-induced cardiac dysfunction and reduces mortality by regulating AMPK alpha 2 dependent signaling pathway, thereby reducing inflammation, oxidative stress, apoptosis, and metabolic alterations.

FRONTIERS IN PHARMACOLOGY (2021)

Review Physiology

Metabolic Complications in Cardiac Aging

Thomas Sithara et al.

Summary: Aging is a process that leads to molecular and cellular changes affecting cardiac function, with altered nutrient contribution to ATP synthesis and impairment of mitochondrial function contributing to cardiac aging and dysfunction.

FRONTIERS IN PHYSIOLOGY (2021)

Review Biochemistry & Molecular Biology

Regulation of Cardiac PKA Signaling by cAMP and Oxidants

Friederike Cuello et al.

Summary: Pathologies such as cancer, inflammatory and cardiac diseases are often associated with long-term oxidative stress, leading to protein dysfunction and failed trials of systemic antioxidant therapy. In cardiac myocytes, cardiac contractility is mainly driven by the beta-adrenoceptor-signaling cascade activating PKA-mediated phosphorylation for positive inotropic and lusitropic effects. Both kinase and phosphatase are redox-sensitive and play crucial roles in regulating cardiac contractile function.

ANTIOXIDANTS (2021)

Article Cardiac & Cardiovascular Systems

LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway

Ning Liu et al.

Summary: The study identified a cardiac metabolic regulator gene called LncHrt, which protects the heart from the effects of myocardial infarction by intervening in metabolic signaling pathways. Overexpression of this gene improves cardiac function, maintains metabolic balance, and mitigates adverse cardiac remodeling responses.

BASIC RESEARCH IN CARDIOLOGY (2021)

Article Chemistry, Analytical

Liquiritin from Radix Glycyrrhizae Protects Cardiac Mitochondria from Hypoxia/Reoxygenation Damage

Vu Thi Thu et al.

Summary: LIQ posthypoxic treatment shows cardioprotective effects by reducing cell death and preserving cardiac mitochondria against HR damage, with significant improvements in cell viability and mitochondrial parameters.

JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY (2021)

Article Cell Biology

Energy-stress-mediated AMPK activation inhibits ferroptosis

Hyemin Lee et al.

NATURE CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Coumestrol ameliorates doxorubicin-induced cardiotoxicity via activating AMPKα

Zhen-Zhong Wu et al.

FREE RADICAL RESEARCH (2020)

Article Endocrinology & Metabolism

PKA Activates AMPK Through LKB1 Signaling in Follicular Thyroid Cancer

Suresh Kari et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Review Biology

AMPK and cardiac remodelling

Yenan Feng et al.

SCIENCE CHINA-LIFE SCIENCES (2018)

Review Cardiac & Cardiovascular Systems

Mechanisms of physiological and pathological cardiac hypertrophy

Michinari Nakamura et al.

NATURE REVIEWS CARDIOLOGY (2018)

Review Biochemistry & Molecular Biology

Structure and Physiological Regulation of AMPK

Yan Yan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Genetics & Heredity

AdipoRon, an adiponectin receptor agonist, attenuates cardiac remodeling induced by pressure overload

Ning Zhang et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2018)

Review Cardiac & Cardiovascular Systems

Loss of Metabolic Flexibility in the Failing Heart

Qutuba G. Karwi et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)

Article Medicine, Research & Experimental

The protective role of liquiritin in high fructose-induced myocardial fibrosis via inhibiting NF-κB and MAPK signaling pathway

Yuan Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

Article Medicine, Research & Experimental

OX40 regulates pressure overload-induced cardiac hypertrophy and remodelling via CD4+ T-cells

Qing-Qing Wu et al.

CLINICAL SCIENCE (2016)

Article Biochemistry & Molecular Biology

Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKa Signalling Pathway

Zhen-Guo Ma et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2016)

Review Cell Biology

AMPK-Sensing Energy while Talking to Other Signaling Pathways

D. Grahame Hardie

CELL METABOLISM (2014)

Article Cardiac & Cardiovascular Systems

AMPK-Dependent Inhibitory Phosphorylation of ACC Is Not Essential for Maintaining Myocardial Fatty Acid Oxidation

Beshay N. M. Zordoky et al.

CIRCULATION RESEARCH (2014)

Article Multidisciplinary Sciences

IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling

Ding-Sheng Jiang et al.

NATURE COMMUNICATIONS (2014)

Article Cardiac & Cardiovascular Systems

Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus

Steven P. Moberly et al.

BASIC RESEARCH IN CARDIOLOGY (2013)

Review Medicine, Research & Experimental

Signaling effectors underlying pathologic growth and remodeling of the heart

Jop H. van Berlo et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Cell Biology

Molecular basis of physiological heart growth: fundamental concepts and new players

Marjorie Maillet et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function

Niels Jessen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2010)

Review Peripheral Vascular Disease

The role of AMP-activated protein kinase in the cardiovascular system

Daisuke Nagata et al.

HYPERTENSION RESEARCH (2010)

Article Biochemistry & Molecular Biology

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

Vinodkumar B. Pillai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Silibinin Attenuates Cardiac Hypertrophy and Fibrosis Through Blocking EGFR-Dependent Signaling

Wen Ai et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2010)

Review Pharmacology & Pharmacy

Molecular targets and regulators of cardiac hypertrophy

Rohini Agrawal et al.

PHARMACOLOGICAL RESEARCH (2010)

Article Cardiac & Cardiovascular Systems

Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1

Vernon W. Dolinsky et al.

CIRCULATION (2009)

Review Biochemistry & Molecular Biology

AMPK: Lessons from transgenic and knockout animals

Benoit Viollet et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2009)

Article Biochemistry & Molecular Biology

Cardiac-specific Deletion of LKB1 Leads to Hypertrophy and Dysfunction

Yasumasa Ikeda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation

Bin Zheng et al.

MOLECULAR CELL (2009)

Review Clinical Neurology

Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice

Weixing Wang et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2008)

Article Cardiac & Cardiovascular Systems

Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy

Anna A. Noga et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

Article Endocrinology & Metabolism

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1

K Sakamoto et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2006)

Review Cardiac & Cardiovascular Systems

Hypertrophy of the heart - A new therapeutic target?

N Frey et al.

CIRCULATION (2004)