4.7 Review

Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer's Disease Complicated With Osteoporosis

Journal

FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.842101

Keywords

Alzheimer's disease; osteoporosis; pathophysiological link; action mechanism; traditional Chinese medicine

Funding

  1. National Natural Science Foundation of China [82004015, 82174079]
  2. Project of Science and Technology Commission of Shanghai Municipality [21S21902600]

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Alzheimer's disease and osteoporosis are progressive degenerative diseases that place a significant burden on the world. They are linked to each other through a pathophysiological connection rather than one causing the other. Traditional Chinese medicine offers valuable therapies that can ameliorate symptoms and provide alternative options for treatment.
Alzheimer's disease (AD) and osteoporosis (OP) are progressive degenerative diseases caused by multiple factors, placing a huge burden on the world. Much evidence indicates that OP is a common complication in AD patients. In addition, there is also evidence to show that patients with OP have a higher risk of AD than those without OP. This suggests that the association between the two diseases may be due to a pathophysiological link rather than one disease causing the other. Several in vitro and in vivo studies have also proved their common pathogenesis. Based on the theory of traditional Chinese medicine, some classic and specific natural Chinese medicines are widely used to effectively treat AD and OP. Current evidence also shows that these treatments can ameliorate both brain damage and bone metabolism disorder and further alleviate AD complicated with OP. These valuable therapies might provide effective and safe alternatives to major pharmacological strategies.

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