Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.824420
Keywords
berberine; bioamine; depression; natural active ingredients; neuroplasticity
Categories
Funding
- National Key R&D Program of China, China [2018YFC1311600]
- National Natural Science Foundation of China, China [81971276, 81871070, 31971078]
- Jilin Science and Technology Agency funds in China, China [20190701078GH, 20210402003GH, 20200301005RQ]
- Scientific Research Foundation of the Education Department of Jilin Province [JJKH20201032KJ]
- Jilin Provincial Finance Department, China [2020SCZT091, JLSCZ b2019051]
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Depression is a widespread and overlooked mood disorder, and natural Chinese medicine berberine has shown promising antidepressant effects. However, further research is needed to understand its efficacy and mechanism in treating depression.
A major type of serious mood disorder, depression is currently a widespread and easily overlooked psychological illness. With the low side effects of natural products in the treatment of diseases becoming the pursuit of new antidepressants, natural Chinese medicine products have been paid more and more attention for their unique efficacy in improving depression. In a view from the current study, the positive antidepressant effects of berberine are encouraging. There is a lot of work that needs to be done to accurately elucidate the efficacy and mechanism of berberine in depression. In this review, the relevant literature reports on the treatment of depression and anxiety by berberine are updated, and the potential pharmacological mechanism of berberine in relieving depression has also been discussed.
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