Journal
FRONTIERS IN NEUROSCIENCE
Volume 16, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2022.824191
Keywords
Parkinson's disease; senescence; alpha-synuclein; astrocyte; microglia
Categories
Funding
- Eastern Nazarene College Instructional and Professional Development Committee
- Pluripotent Diagnostics
Ask authors/readers for more resources
Parkinson's disease is a common neurodegenerative disease without a cure. While research often focuses on neurons, this review highlights the important role of neuroglia in the disease. Factors such as oxidative stress and neuroinflammation are discussed, along with the potential therapeutic avenue of senolytics for PD.
Parkinson's disease (PD) is the most common movement disorder and the second most prevalent neurodegenerative disease after Alzheimer's disease. Despite decades of research, there is still no cure for PD and the complicated intricacies of the pathology are still being worked out. Much of the research on PD has focused on neurons, since the disease is characterized by neurodegeneration. However, neuroglia has become recognized as key players in the health and disease of the central nervous system. This review provides a current perspective on the interactive roles that alpha-synuclein and neuroglial senescence have in PD. The self-amplifying and cyclical nature of oxidative stress, neuroinflammation, alpha-synucleinopathy, neuroglial senescence, neuroglial chronic activation and neurodegeneration will be discussed. Finally, the compelling role that senolytics could play as a therapeutic avenue for PD is explored and encouraged.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available