4.6 Review

Advancing the Understanding of Acupoint Sensitization and Plasticity Through Cutaneous C-Nociceptors

Related references

Note: Only part of the references are listed.
Article Neurosciences

A functional subdivision within the somatosensory system and its implications for pain research

Qiufu Ma

Summary: The somatosensory system is proposed to be functionally subdivided into the exteroceptive branch and the interoceptive branch, with distinct roles in detecting external threats and sensing body integrity disruptions respectively. This subdivision challenges the current dilemma in pain research field and highlights potential translation issues in therapies from preclinical studies.

NEURON (2022)

Article Biotechnology & Applied Microbiology

Epineural optogenetic activation of nociceptors initiates and amplifies inflammation

Frederic Michoud et al.

Summary: Research shows that activation of pain-triggering sensory neurons induces an immune response.

NATURE BIOTECHNOLOGY (2021)

Article Neurosciences

Cutaneous Hypersensitivity as an Indicator of Visceral InflammationviaC-Nociceptor Axon Bifurcation

Yehong Fang et al.

Summary: The study provides evidence of axon bifurcation in primary C-nociceptive neurons leading to cutaneous hypersensitivity in visceral inflammation, indicating a potential link between pain on the body surface and disorders in internal organs.

NEUROSCIENCE BULLETIN (2021)

Article Integrative & Complementary Medicine

The Preventive Value of Acupoint Sensitization for Patients with Stable Angina Pectoris: A Randomized, Double-Blind, Positive-Controlled, Multicentre Trial

Shourui Huang et al.

Summary: Acupressure at acupoints with high sensitivity to pain was more effective in reducing the frequency of stable angina pectoris episodes compared to acupoints with low sensitivity. Patients in the high-sensitivity group also reported higher treatment satisfaction. The study suggests that acupressure may be a beneficial intervention for preventing episodes of stable angina pectoris.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

Article Multidisciplinary Sciences

A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis

Shenbin Liu et al.

Summary: The study reveals that the specificity of sensory neurons is crucial for driving specific autonomic pathways and anti-inflammatory effects at specific acupoints.

NATURE (2021)

Article Biochemistry & Molecular Biology

Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis

Shiqun Zhang et al.

Summary: A subset of sensory nonpeptidergic neurons expressing MrgprD play a crucial role in regulating skin inflammation, suppressing mast cell hyperresponsiveness and cutaneous immune homeostasis via glutamate release.
Review Immunology

Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States

Daniel B. Lowy et al.

Summary: Bidirectional interaction between the peripheral immune and nervous systems plays a crucial role in maintaining homeostasis and responding to noxious stimuli. The skin is a highly complex biological structure where sensory nerve terminals and immune cells coexist. Sensory neurons regulate cutaneous immune responses through neuropeptides, while immune cells modulate sensory neurons through mediators.

FRONTIERS IN IMMUNOLOGY (2021)

Review Pharmacology & Pharmacy

The role of neutrophils in neuro-immune modulation

Alexandre Kanashiro et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Neurosciences

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain

Dustin P. Green et al.

NEURON (2019)

Review Biochemistry & Molecular Biology

The Dynamics of the Skin's Immune System

Alan V. Nguyen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity

Jonathan A. Cohen et al.

Review Integrative & Complementary Medicine

Understanding Acupoint Sensitization: A Narrative Review on Phenomena, Potential Mechanism, and Clinical Application

Huijuan Tan et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

Article Multidisciplinary Sciences

Specialized cutaneous Schwann cells initiate pain sensation

Hind Abdo et al.

SCIENCE (2019)

Review Cell Biology

Nociceptor plasticity: A closer look

Maria Caterina Pace et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Review Immunology

Mast cell-neural interactions contribute to pain and itch

Kalpna Gupta et al.

IMMUNOLOGICAL REVIEWS (2018)

Editorial Material Integrative & Complementary Medicine

What Is the Point? The Problem with Acupuncture Research That No One Wants to Talk About

Helene M. Langevin et al.

JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE (2018)

Review Immunology

Skin neurogenic inflammation

Jae Eun Choi et al.

SEMINARS IN IMMUNOPATHOLOGY (2018)

Review Immunology

Origins of antidromic activity in sensory afferent fibers and neurogenic inflammation

Linda S. Sorkin et al.

SEMINARS IN IMMUNOPATHOLOGY (2018)

Article Neurosciences

Neuropeptides SP and CGRP Underlie the Electrical Properties of Acupoints

Yu Fan et al.

FRONTIERS IN NEUROSCIENCE (2018)

Article Allergy

Substance P activates Mas-related G protein-coupled receptors to induce itch

Ehsan Azimi et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Multidisciplinary Sciences

Acupuncture points can be identified as cutaneous neurogenic inflammatory spots

Do-Hee Kim et al.

SCIENTIFIC REPORTS (2017)

Review Medicine, Research & Experimental

Association of inflammatory mediators with pain perception

S. Ronchetti et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Review Integrative & Complementary Medicine

Acupuncture Points and Their Relationship with Multireceptive Fields of Neurons

Salvador Quiroz-Gonzalez et al.

JOURNAL OF ACUPUNCTURE AND MERIDIAN STUDIES (2017)

Article Integrative & Complementary Medicine

Cutaneous neurogenic inflammation in the sensitized acupoints induced by gastric mucosal injury in rats

Wei He et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)

Review Integrative & Complementary Medicine

Can Ashi points stimulation have specific effects on shoulder pain? A systematic review of randomized controlled trials

Wang Kang-feng et al.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2016)

Editorial Material Integrative & Complementary Medicine

Acupoint Sensitization, Acupuncture Analgesia, Acupuncture on Visceral Functional Disorders, and Its Mechanism

Xiaochun Yu et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2015)

Review Biochemistry & Molecular Biology

Mast Cell-Mediated Mechanisms of Nociception

Anupam Aich et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Article Biochemistry & Molecular Biology

Local cutaneous nerve terminal and mast cell responses to manual acupuncture in acupoint LI4 area of the rats

Mei-Ling Wu et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2015)

Article Biochemistry & Molecular Biology

Mast cells: Versatile gatekeepers of pain

Devavani Chatterjea et al.

MOLECULAR IMMUNOLOGY (2015)

Review Anesthesiology

What is the Acupoint? A preliminary review of Acupoints

Fang Li et al.

PAIN MEDICINE (2015)

Article Multidisciplinary Sciences

CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity

Nader Ghasemlou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Integrative & Complementary Medicine

Changes in Responses of Neurons in Spinal and Medullary Subnucleus Reticularis Dorsalis to Acupoint Stimulation in Rats with Visceral Hyperalgesia

Ling-Ling Yu et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014)

Review Neurosciences

Nociceptive primary afferents: they have a mind of their own

Susan M. Carlton

JOURNAL OF PHYSIOLOGY-LONDON (2014)

Article Multidisciplinary Sciences

Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation

Lorena Riol-Blanco et al.

NATURE (2014)

Review Neurosciences

Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis

Bakri M. Assas et al.

FRONTIERS IN NEUROSCIENCE (2014)

Article Integrative & Complementary Medicine

Study on the Dynamic Compound Structure Composed of Mast Cells, Blood Vessels, and Nerves in Rat Acupoint

Luo Mingfu et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

Article Integrative & Complementary Medicine

Peripheral and Spinal Mechanisms of Acupoint Sensitization Phenomenon

Pei-Jing Rong et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

Review Integrative & Complementary Medicine

Characterization of Deqi Sensation and Acupuncture Effect

Xing-Yue Yang et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

Article Gastroenterology & Hepatology

Long-term sensitization of mechanosensitive and -insensitive afferents in mice with persistent colorectal hypersensitivity

Bin Feng et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2012)

Article Integrative & Complementary Medicine

Observation of Pain-Sensitive Points along the Meridians in Patients with Gastric Ulcer or Gastritis

Hui Ben et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012)

Article Gastroenterology & Hepatology

Characterization of silent afferents in the pelvic and splanchnic innervations of the mouse colorectum

Bin Feng et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2011)

Article Integrative & Complementary Medicine

Forgotten Features of Head Zones and Their Relation to Diagnostically Relevant Acupuncture Points

Florian Beissner et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2011)

Article Medicine, General & Internal

Active Albuterol or Placebo, Sham Acupuncture, or No Intervention in Asthma

Michael E. Wechsler et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Neurosciences

Afferent nerve fibers and acupuncture

Fusako Kagitani et al.

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2010)

Review Biochemistry & Molecular Biology

Nociceptor sensitization in pain pathogenesis

Michael S. Gold et al.

NATURE MEDICINE (2010)

Review Neurosciences

Neuronal circuitry for pain processing in the dorsal horn

Andrew J. Todd

NATURE REVIEWS NEUROSCIENCE (2010)

Review Medicine, General & Internal

Acupuncture for peripheral joint osteoarthritis

Eric Manheimer et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2010)

Review Biochemistry & Molecular Biology

Cellular and Molecular Mechanisms of Pain

Allan I. Basbaum et al.

Article Neurosciences

Distribution of P2X3-Immunoreactive Fibers in Hairy and Glabrous Skin of the Rat

Anna M. W. Taylor et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2009)

Review Clinical Neurology

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

Alban Latremoliere et al.

JOURNAL OF PAIN (2009)

Review Immunology

Skin immune sentinels in health and disease

Frank O. Nestle et al.

NATURE REVIEWS IMMUNOLOGY (2009)

Article Integrative & Complementary Medicine

Can classical acupuncture points and trigger points be compared in the treatment of pain disorders? Birch's analysis revisited

Peter T. Dorsher

JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE (2008)

Article Rehabilitation

Morphological analysis of human acupuncture points through immunohistochemistry

Franziska Wick et al.

AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION (2007)

Review Neurosciences

Noradrenergic pain modulation

Antti Pertovaara

PROGRESS IN NEUROBIOLOGY (2006)

Article Neurosciences

Role of unmyelinated fibers in electroacupuncture cardiovascular responses

SC Tjen-A-Looi et al.

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2005)

Article Clinical Neurology

Complex regional pain syndrome

F Birklein

JOURNAL OF NEUROLOGY (2005)

Article Integrative & Complementary Medicine

Trigger point-acupuncture point correlations revisited

S Birch

JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE (2003)

Article Pharmacology & Pharmacy

Cellular mechanisms of neurogenic inflammation

JD Richardson et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)

Review Multidisciplinary Sciences

Neuroscience - Neuronal plasticity: Increasing the gain in pain

CJ Woolf et al.

SCIENCE (2000)

Article Neurosciences

Which nerve fibers mediate the axon reflex flare in human skin?

M Schmelz et al.

NEUROREPORT (2000)