Journal
EMERGING MICROBES & INFECTIONS
Volume 11, Issue 1, Pages 1425-1434Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/22221751.2022.2069515
Keywords
Avian influenza viruses; Mongolia; 2; 3; 4; 4h; hemagglutination inhibition
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Funding
- Priority Research Centres Programme from the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2015R1A6A1A03032236]
- Bio and Medical Technology Development Program of the National Research Foundation (NRF) - Government of the Republic of Korea (MSIT) [2018M3A9H4055194]
- National Research Foundation of Korea [2018M3A9H4055194] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Several novel highly pathogenic avian influenza A(H5N6) viruses with mammalian infection markers were reported in Mongolia in 2020. This study isolated and evaluated two new genotypes of A(H5N6) subtype, finding that they were less virulent in mice compared to previously identified H5 human isolates. Additionally, their antigenicity differed from other H5 clade 2.3.4.4 viruses, suggesting the need for continued evaluation and potential vaccine development.
Several novel highly pathogenic avian influenza (HPAIVs) A(H5N6) viruses were reported in Mongolia in 2020, some of which included host-specific markers associated with mammalian infection. However, their pathogenicity has not yet been investigated. Here, we isolated and evaluate two novel genotypes of A(H5N6) subtype in Mongolia during 2018-2019 (A/wildDuck/MN/H5N6/2018-19). Their evolution pattern and molecular characteristics were evaluated using gene sequencing and their pathogenicity was determined using a mouse model. We also compared their antigenicity with previous H5 Clade 2.3.4.4 human isolates by cross-hemagglutination inhibition (HI). Our data suggests that A/wildDuck/MN/H5N6/2018-19 belongs to clade 2.3.4.4h, and maintains several residues associated with mammal adaptation. In addition, our evaluations revealed that their isolates are less virulent in mice than the previously identified H5 human isolates. However, their antigenicity is distinct from other HPAIVs H5 clade 2.3.4.4, thus supporting their continued evaluation as potential infection risks and the preparation of novel candidate vaccines for their neutralization.
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