Journal
CHEMELECTROCHEM
Volume 9, Issue 5, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/celc.202101411
Keywords
C-H activation; electrochemistry; gram-scale; metal-free; trifluoromethylation
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Funding
- National Key Research and Development Program of China [2019YFA0905000]
- National Natural Science Foundation of China [21776130, 21878145, 22078150]
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This article presents a metal-catalyst-free and external-oxidant-free electrochemical oxidative radical C-H ortho-trifluoromethylation. The reaction specifically occurs at the ortho-position of anilides without directing groups. Various anilides show good tolerance and provide the desired products in moderate to good yields. Additionally, the gram-scale amplified product of benzanilide is obtained with a yield of 64%, demonstrating its potential for application.
A metal-catalyst-free and external-oxidant-free electrochemical oxidative radical C-H ortho-trifluoromethylation is presented. The reaction specifically occurred at the ortho-position of anilides without directing groups. Various anilides showed good tolerance to provide the desired products in moderate to good yields. In addition, the gram-scale amplified product of benzanilide was obtained with a yield of 64 %, which proved that it has a certain application potential.
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