The understanding of Parkinson's disease through genetics and new therapies

Review Cell Biology

From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease?

Rita Caridade Silva et al.

Summary: Parkinson's disease is a common neurodegenerative disease, and the current treatment focuses on symptom relief rather than prevention of neuronal damage. Therefore, the development of neuroprotective and disease-modifying strategies is crucial. Stem cell secretome has shown promise as a potential alternative for regenerative medicine in Parkinson's disease, as it can modulate the viability and preservation of dopaminergic neurons.

NEURAL REGENERATION RESEARCH (2022)

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Article Immunology

Neurological disorders in HIV: Hope despite challenges

Olivier Uwishema et al.

Summary: HIV is a virus that attacks the human immune system and causes various diseases, including neurological complications. The pathogenesis of HIV-associated neurological disorders is poorly understood, which limits treatment options. Despite the availability of antiretroviral therapies, the risk of developing neurological complications remains relatively high among HIV patients.

IMMUNITY INFLAMMATION AND DISEASE (2022)

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Review Biochemistry & Molecular Biology

LRRK2 Targeting Strategies as Potential Treatment of Parkinson's Disease

Dominika Natalia Wojewska et al.

Summary: This review provides a comprehensive overview of the current state of the art, presenting recent developments and challenges in developing LRRK2 inhibitors, and discussing extensively the potential targeting strategies from the protein perspective. As currently there are three LRRK2-targeting agents in clinical trials, more developments are predicted in the upcoming years.

BIOMOLECULES (2021)

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Review Chemistry, Medicinal

Current Therapies in Clinical Trials of Parkinson's Disease: A 2021 Update

E. Maruthi Prasad et al.

Summary: Parkinson's disease is a progressive neurodegenerative disorder without a cure, but treatments are available to improve symptoms. Clinical trials for PD treatment have been increasing, with a focus on drugs and therapies, predominantly in phases I and II, utilizing various treatment modalities and drugs.

PHARMACEUTICALS (2021)

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Article Geriatrics & Gerontology