Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 27, Issue 10, Pages 972-985Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2016.1175405
Keywords
Hydrosoluble chitosan; thiolated; pH responsive; renal fibrosis; targeting drug
Funding
- National Nature Science Foundation of China [51273070, 31201751]
- Natural Science Foundation of Guangdong Province [2014A030313232]
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About 50% N-acetylation-thiolated chitosan possessing good water solubility was modified from commercial low-molecular-weight chitosan. Chitosan performed obvious target toward renal tubular epithelial cells, and bivalent cobalt ions improved the renal fibrosis inflammation significantly. There were many complexation sites on chitosan after being modified with sulfydryl. So sulfydryl played a role of connecting bridge between chitosan and cobalt ions. Then, this N-acetylation-thiolated chitosan cobalt (NTCC) nanocomplex was designed. The nanocomplex showed excellent stability under normal physiological conditions, and cobalt would be released from the biomaterials in acidic environment. As it was affected by inflammation, the pH in renal fibrosis lesion region was acidic. So there was a specific drug release process happening in lesion region. And drug release efficiency was determined by acidity, which demonstrated that lower the acidity, the faster and more the cobalt ion release. When this nanocomplex was intraperitoneally injected into ureter-obstructed mice, obvious attenuation of fibrotic progression was shown. It was demonstrated that NTCC exhibited special renal-targeting capacity and could be chosen as drug for treating renal fibrosis.
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