Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 27, Issue 10, Pages 1017-1028Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2016.1175784
Keywords
Gelatin; silicone; quaternary ammonium; antibacterial; surface free energy
Funding
- National Natural Science Foundation of China [21406121, 21376125]
- Key Projects in the National Science & Technology Pillar Program [2014BAE02B00]
- Program for Scientific Research Innovation Team in Colleges and Universities of Shandong Province, P.R. China
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Gelatin (GE) was modified with epoxy silicone quaternary ammonium salt (EPSiQA) under alkaline conditions (pH 10-11). Silyl and quaternary ammonium groups were linked to gelatin skeleton simultaneously. It was illustrated by XRD and DSC that the short-range order of GE is destroyed and the glass transition temperature (Tg) of GE drops 10 degrees C after modification. The measured contact angles and surface free energy calculated by Owens-Wendt equation showed that the surface energy of modified gelatin EPSiQA-GE is mainly contributed by the dispersive component of non-polarity silicone groups, the hydrophobility of EPSiQA-GE increases with the increase of grafted silicone units in gelatin. The results of minimum inhibitory concentration indicated that EPSiQA-GE has bactericidal property against Gram-positive bacteria, Gram-negative bacteria and has no antibacterial effect on mold.
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