Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 31, Issue 5, Pages 721-729Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328216661557
Keywords
Sodium alginate; cysteine methyl ester hydrochloride; in situ hydrogel; wound healing; hemostasis
Funding
- National Natural Science Foundation of China [21274039]
- specialized research fund for the doctoral program of higher education [20130074110007]
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An in situ formed hydrogel was synthesized by sodium alginate and cysteine methyl ester, which turned the sodium alginate into thiolated alginate (SA-SH). SA-SH can in situ formed into hydrogel (SA-SS-SA) with a large amount of water through covalent bond in less than 20s. The structure characterization showed that the mechanism of SA-SH gelation was thiol-disulfide transformation. The rheology and cytotoxicity experiments of SA-SS-SA hydrogel were also investigated, which indicated that SA-SS-SA hydrogel had an appropriate mechanical strength as well as an excellent biocompatibility. The SA-SS-SA hydrogel would degrade under certain conditions after a few days and its mechanism was disulfide alkaline reduction. Finally, the hemostatic property of SA-SH was tested by rat tail amputation experiment. The time to hemostasis of rat reduced from 8.26min to 3.24min, which proved that SA-SH had an excellent hemostatic property.
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