Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 30, Issue 9, Pages 1407-1416Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328216629822
Keywords
Aluminum-doped zinc oxide nanoparticles; TSLP; caspase-1; mast cells
Funding
- Technology Innovation Program - Ministry of Trade, Industry and Energy (MI, Korea) [10048910]
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Zinc oxide nanoparticles (ZO-NPs) are used as antimicrobials, anti-inflammatories, and to treat cancer. However, although ZO-NPs have excellent efficiency and specificity, their cytotoxicity is higher than that of micron-sized zinc oxide. Doping ZO-NPs with aluminum can improve therapeutic efficacy, but the biological effects and mechanisms involved have not been elucidated. Here, we reported the efficacy of aluminum-doped ZO-NP (AZO) on thymic stromal lymphopoietin (TSLP) production and caspase-1 activation in human mast cell line, HMC-1 cells. AZO significantly reduced TSLP levels as well as interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)- without inducing cytotoxicity. Furthermore, AZO more effectively reduced TSLP, IL-6, IL-8, and TNF- levels than ZO-NP. The levels of inflammatory cytokine mRNA were also reduced by AZO treatment. AZO blocked production of IL-1 and activations of caspase-1 and nuclear factor-B by inhibiting IB kinase and receptor interacting protein 2. In addition, AZO attenuated phosphorylation of mitogen-activated protein kinases, such as extracellular signal-regulated kinase, c-Jun N-terminal kinases, and p38. These findings provide evidence that AZO improves anti-inflammatory properties and offer a safe and effective potential treatment option.
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