Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 31, Issue 3, Pages 464-474Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328216648809
Keywords
Composite hydrogel; hyaluronic acid; hydroxyapatite; dermal filler; bioactivity; durability
Funding
- Small and Medium Business Administration (SMBA, Korea) [S2174750]
- Korea Technology & Information Promotion Agency for SMEs (TIPA) [S2174750] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Hyaluronic acid (HAc)-hydroxyapatite (HAp) composite hydrogels were developed to improve the biostability and bioactivity of HAc for dermal filler applications. Two kinds of HAc-HAp composite fillers were generated: HAcmicroHAp and HAc-nanoHAp composites. HAc-microHAp was fabricated by mixing HAp microspheres with HAc hydrogels, and HAc-nanoHAp was made by in situ precipitation of nano-sized HAp particles in HAc hydrogels. Emphasis was placed on the effect of HAp on the durability and bioactivity of the fillers. Compared with the pure HAc filler, all of the HAc-HAp composite fillers exhibited significant improvements in volumetric maintenance based on in vivo tests owing to their reduced water content and higher degree of biointegration between the filler and surrounding tissues. HAc-HAp composite fillers also showed noticeable enhancement in dermis recovery, promoting collagen and elastic fiber formation. Based on their long-lasting durability and bioactivity, HAc-HAp composite fillers have great potential for soft tissue augmentation with multifunctionality.
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