Journal
JOURNAL OF NANOBIOTECHNOLOGY
Volume 20, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12951-022-01307-x
Keywords
Drug delivery; Lung; Pulmonary infectious disease; Targeting; Therapeutic strategies
Funding
- National Natural Science Foundation of China [81773654]
- 111 Project [B18035]
- Fundamental Research Funds for the Central Universities
- Sichuan University College Student Innovation and Entrepreneurship Training Program
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Pulmonary drug delivery is an important approach for treating infectious lung diseases, with unique advantages. This review article examines literature on pulmonary delivery strategies in the past decade, offering new perspectives for future treatments.
Pulmonary drug delivery is a highly attractive topic for the treatment of infectious lung diseases. Drug delivery via the pulmonary route offers unique advantages of no first-pass effect and high bioavailability, which provides an important means to deliver therapeutics directly to lung lesions. Starting from the structural characteristics of the lungs and the biological barriers for achieving efficient delivery, we aim to review literatures in the past decade regarding the pulmonary delivery strategies used to treat infectious lung diseases. Hopefully, this review article offers new insights into the future development of therapeutic strategies against pulmonary infectious diseases from a delivery point of view.
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