Comparison of Multisystem Inflammatory Syndrome in Children-Related Myocarditis, Classic Viral Myocarditis, and COVID-19 Vaccine-Related Myocarditis in Children

Article Pediatrics

Multisystem Inflammatory Syndrome in Children: Survey of Protocols for Early Hospital Evaluation and Management

Matthew L. Dove et al.

Summary: There are many similarities yet key differences between hospital protocols for MIS-C. These findings can help healthcare providers learn from others regarding options for managing MIS-C.

JOURNAL OF PEDIATRICS (2021)

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Article Immunology

Differences Between Pediatric Acute Myocarditis Related and Unrelated to SARS-CoV-2

Vladislav A. Vukomanovic et al.

Summary: Patients with acute myocarditis related to SARS-CoV-2 showed higher CRP levels, diverse clinical presentations, shorter duration of inotropic drug use, and prompt recovery of left ventricle systolic function compared to those unrelated to SARS-CoV-2.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2021)

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Article Pediatrics

Factors linked to severe outcomes in multisystem inflammatory syndrome in children (MIS-C) in the USA a retrospective surveillance study

Joseph Y. Abrams et al.

Summary: Factors such as age, race, clinical symptoms, and laboratory markers were found to be associated with severe outcomes in patients with MIS-C. These findings highlight the importance of early recognition and prompt management for patients with MIS-C.

LANCET CHILD & ADOLESCENT HEALTH (2021)

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Review Cardiac & Cardiovascular Systems

Trends in Acute Myocarditis Related Pediatric Hospitalizations in the United States, 2007-2016

Rhythm Vasudeva et al.

Summary: This study found that the incidence of pediatric acute myocarditis in the United States has been increasing annually, while the in-hospital mortality rate has been decreasing. The occurrence of congestive heart failure remained stable, while hospitalization costs have been increasing annually with stable length of stay. Future studies are needed to investigate long-term outcomes related to acute myocarditis.

AMERICAN JOURNAL OF CARDIOLOGY (2021)

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Article Pediatrics

Symptomatic Acute Myocarditis in 7 Adolescents After Pfizer-BioNTech COVID-19 Vaccination

Mayme Marshall et al.

Summary: This report presents 7 cases of acute myocarditis or myopericarditis in healthy male adolescents following the second dose of Pfizer-BioNTech COVID-19 vaccination, with patients rapidly recovering their symptoms through treatment with nonsteroidal anti-inflammatory drugs, intravenous immunoglobulin, and corticosteroids. The potential association between vaccine administration and myocarditis requires further monitoring and investigation.

PEDIATRICS (2021)

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Article Public, Environmental & Occupational Health

Use of mRNA COVID-19 Vaccine After Reports of Myocarditis Among Vaccine Recipients: Update from the Advisory Committee on Immunization Practices — United States, June 2021

Julia W. Gargano et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Article Cardiac & Cardiovascular Systems

Myocarditis Following Immunization With mRNA COVID-19 Vaccines in Members of the US Military

Jay Montgomery et al.

Summary: This study investigated cases of myocarditis occurring in male patients within the US Military Health System after receiving mRNA COVID-19 vaccines between January and April 2021. A total of 23 male patients presented with acute chest pain within 4 days post-vaccination, with elevated troponin levels and findings consistent with myocarditis on imaging. The number of cases observed was higher than expected after a second dose of the vaccine among male military members.

JAMA CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination

Han W. Kim et al.

Summary: This study described 7 patients with acute myocarditis, 4 of whom had received mRNA COVID-19 vaccination. All patients presented with severe chest pain, biomarker evidence of myocardial injury, and were hospitalized. Cardiac magnetic resonance imaging findings were typical for myocarditis. Further investigation is needed to determine associations of COVID-19 vaccination and myocarditis.

JAMA CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems