Related references
Note: Only part of the references are listed.TrkB Promotes Breast Cancer Metastasis via Suppression of Runx3 and Keap1 Expression
Min Soo Kim et al.
MOLECULES AND CELLS (2016)
MCM: one ring to rule them all
Tom D. Deegan et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2016)
A new MCM modification cycle regulates DNA replication initiation
Lei Wei et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
USP7 is a SUMO deubiquitinase essential for DNA replication
Emilio Lecona et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
A new MCM modification cycle regulates DNA replication initiation
Lei Wei et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
USP7 is a SUMO deubiquitinase essential for DNA replication
Emilio Lecona et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Tethering of SCFDia2 to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase
Timurs Maculins et al.
CURRENT BIOLOGY (2015)
Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage
Romain Drissi et al.
MOLECULAR & CELLULAR PROTEOMICS (2015)
The mechanism of DNA replication termination in vertebrates
James M. Dewar et al.
NATURE (2015)
A mechanism for the suppression of homologous recombination in G1 cells
Alexandre Orthwein et al.
NATURE (2015)
Regulated eukaryotic DNA replication origin firing with purified proteins
Joseph T. P. Yeeles et al.
NATURE (2015)
Substrate Trapping Proteomics Reveals Targets of the beta TrCP2/FBXW11 Ubiquitin Ligase
Tai Young Kim et al.
MOLECULAR AND CELLULAR BIOLOGY (2015)
Cancer-Derived Mutations in KEAP1 Impair NRF2 Degradation but not Ubiquitination
Bridgid E. Hast et al.
CANCER RESEARCH (2014)
A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA
Stefan A. Samel et al.
GENES & DEVELOPMENT (2014)
Spotlite: Web Application and Augmented Algorithms for Predicting Co-Complexed Proteins from Affinity Purification - Mass Spectrometry Data
Dennis Goldfarb et al.
JOURNAL OF PROTEOME RESEARCH (2014)
Functional Role of Autophagy-Mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity
Robin Mathew et al.
MOLECULAR CELL (2014)
Comprehensive molecular profiling of lung adenocarcinoma
Eric A. Collisson et al.
NATURE (2014)
ProteomeXchange provides globally coordinated proteomics data submission and dissemination
Juan A. Vizcaino et al.
NATURE BIOTECHNOLOGY (2014)
mUbiSiDa: A Comprehensive Database for Protein Ubiquitination Sites in Mammals
Tong Chen et al.
PLOS ONE (2014)
Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication
Marija Maric et al.
SCIENCE (2014)
Polyubiquitylation drives replisome disassembly at the termination of DNA replication
Sara Priego Moreno et al.
SCIENCE (2014)
Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells
Liam Baird et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
Proteomic Analysis of Ubiquitin Ligase KEAP1 Reveals Associated Proteins That Inhibit NRF2 Ubiquitination
Bridgid E. Hast et al.
CANCER RESEARCH (2013)
Parallel SCF Adaptor Capture Proteomics Reveals a Role for SCFFBXL17 in NRF2 Activation via BACH1 Repressor Turnover
Meng-Kwang Marcus Tan et al.
MOLECULAR CELL (2013)
Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA
Jingchuan Sun et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Insight into the Intermolecular Recognition Mechanism between Keap1 and IKKβ Combining Homology Modelling, Protein-Protein Docking, Molecular Dynamics Simulations and Virtual Alanine Mutation
Zheng-Yu Jiang et al.
PLOS ONE (2013)
The PS1 Hairpin of Mcm3 Is Essential for Viability and for DNA Unwinding In Vitro
Simon K. W. Lam et al.
PLOS ONE (2013)
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Jianjiong Gao et al.
SCIENCE SIGNALING (2013)
Regulating DNA Replication in Eukarya
Khalid Siddiqui et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
Marcin Imielinski et al.
CELL (2012)
Functional dissection of Nrf2-dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA
Ji-Hee Kim et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
Kai Takaya et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein
Nathan D. Camp et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
Ethan Cerami et al.
CANCER DISCOVERY (2012)
Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer
Panagiotis A. Konstantinopoulos et al.
CANCER RESEARCH (2011)
Global Identification of Modular Cullin-RING Ligase Substrates
Michael J. Emanuele et al.
CELL (2011)
Eukaryotic Origin-Dependent DNA Replication In Vitro Reveals Sequential Action of DDK and S-CDK Kinases
Ryan C. Heller et al.
CELL (2011)
Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease
Maria Cecilia Barone et al.
DISEASE MODELS & MECHANISMS (2011)
The structural basis for MCM2-7 helicase activation by GINS and Cdc45
Alessandro Costa et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylation
Jeong-Eun Kim et al.
CELLULAR SIGNALLING (2010)
Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases
Shruti Singh et al.
FREE RADICAL RESEARCH (2010)
Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains
Toshihiko Ogura et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease
Gerasimos P. Sykiotis et al.
SCIENCE SIGNALING (2010)
Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure
Hyun Ju Kim et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2010)
Concerted Loading of Mcm2-7 Double Hexamers around DNA during DNA Replication Origin Licensing
Dirk Remus et al.
CELL (2009)
Eukaryotic DNA replication control: Lock and load, then fire
Dirk Remus et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
Targeting the redox sensitive Nrf2-Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones
Giovanni E. Mann et al.
CURRENT OPINION IN PHARMACOLOGY (2009)
The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress
Truyen Nguyen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ
Dung-Fang Lee et al.
MOLECULAR CELL (2009)
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
Tsutonm Ohta et al.
CANCER RESEARCH (2008)
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
Xiao-Jun Wang et al.
CARCINOGENESIS (2008)
Keapl/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila
Gerasimos P. Sykiotis et al.
DEVELOPMENTAL CELL (2008)
Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability
Matthew L. Bochman et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Physiological significance of reactive cysteine residues of keap1 in determining Nrf2 activity
Tae Yamamoto et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Crystal structure of a near-full-length archaeal MCM: Functional insights for an AAA plus hexameric helicase
Aaron S. Brewster et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Subcellular localization and cytoplasmic complex status of endogenous Keap1
Yoriko Watai et al.
GENES TO CELLS (2007)
PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated keap1-dependent ubiquitin ligase complex
Shih-Ching Lo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum
Yiguo Zhang et al.
BIOCHEMICAL JOURNAL (2006)
Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain - Inhibition of nuclear translocation and transacting function
Weiping Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model
KI Tong et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Oxidative and electophilic stresses activate Nrf2 through inhibition of ubiquitination activity if Keap1
A Kobayashi et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation
M Snyder et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
BTB protein keap1 targets antioxidant transcription factor nrf2 for ubiquitination by the cullin 3-Roc1 ligase
M Furukawa et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
N Wakabayashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress
T Nguyen et al.
FREE RADICAL BIOLOGY AND MEDICINE (2004)
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
DD Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases
D Cortez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles
K Itoh et al.
FREE RADICAL BIOLOGY AND MEDICINE (2004)
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
M McMahon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element - Degradation of Nrf2 by the 26 S proteasome
T Nguyen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
DD Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3
Y Takei et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Mcm3 is polyubiquitinated during mitosis before establishment of the pre-replication complex
IH Cheng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
AT Dinkova-Kostova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)