Journal
CANCER LETTERS
Volume 368, Issue 1, Pages 7-13Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2015.07.039
Keywords
Tumor microenvironment; Drug resistance; Combination therapy
Categories
Funding
- National Natural Science Foundation of China [81470685]
- Natural Science Foundation of Zhejiang Province [R15H080001]
- Fundamental Research Funds for the Central Universities [2014QNA6003]
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Tumor cells constantly interact with the surrounding microenvironment. Increasing evidence indicates that targeting the tumor microenvironment could complement traditional treatment and improve therapeutic outcomes for these malignancies. In this paper, we review new insights into the tumor microenvironment, and summarize selected examples of the cross-talk between tumor cells and their microenvironment, which have enhanced our understanding of pathophysiology of the microenvironment. We believe that this rapidly moving field promises many more to come, and they will guide the rational design of combinational therapies for success in cancer eradication. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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