Journal
CANCER LETTERS
Volume 361, Issue 1, Pages 13-21Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2015.03.002
Keywords
Long noncoding RNAs; Colorectal cancer (CRC); Tumorigenesis; Therapeutic targets
Categories
Funding
- Natural Science Foundation of Heilongjiang Province for youth [QC2013C089]
- Science and Technology Research Project of Education Department in Heilongjiang Province [12531226]
- Postdoctoral Foundation of Heilongjiang Province [LBH-Z12172/LBH-TZ0415]
- Research Foundation for the Doctoral Program of Higher Education [20122307110002]
- Science and Technology Project of Heilongjiang Province [2013G1002]
- Harbin and Yu weihan academician fund for distinguished young Scholars of Harbin medical university [2014RFXGJ053]
Ask authors/readers for more resources
Colorectal cancer (CRC) is the most common type of cancer in the world. Despite its commonness, the underlying mechanism of CRC is not completely understood. Long noncoding RNAs (lncRNAs) have received increased attention with the development of whole genome and transcriptome sequencing technologies. Recent findings reveal that lncRNAs are implicated in serial steps of cancer development. These IncRNAs interact with DNA, RNA, protein molecules and/or their combinations, acting as an essential regulator in chromatin organization, and transcriptional and post-transcriptional regulation. In this review, we highlight recent findings of emerging roles for lncRNAs in CRC and discuss rapid translational lncRNA research for clinical application in diagnosis, prognosis and potential treatment. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
