Related references
Note: Only part of the references are listed.Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles
Michael V. LeVine et al.
BIOCHEMISTRY (2016)
Computational approaches to detect allosteric pathways in transmembrane molecular machines
Sebastian Stolzenberg et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2016)
Allosteric Mechanisms of Molecular Machines at the Membrane: Transport by Sodium-Coupled Symporters
Michael V. LeVine et al.
CHEMICAL REVIEWS (2016)
A conserved leucine occupies the empty substrate site of LeuT in the Na+-free return state
Lina Malinauskaite et al.
NATURE COMMUNICATIONS (2016)
Spontaneous Inward Opening of the Dopamine Transporter Is Triggered by PIP2-Regulated Dynamics of the N-Terminus
George Khelashvili et al.
ACS CHEMICAL NEUROSCIENCE (2015)
Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter
Christian B. Billesbolle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter: Sodium Symporters
Sebastian Stolzenberg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine
Aravind Penmatsa et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
Octopamine mediates starvation-induced hyperactivity in adult Drosophila
Zhe Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2-containing membranes
George Khelashvili et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2015)
X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine
Aravind Penmatsa et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
Microseconds Simulations Reveal a New Sodium-binding Site and the Mechanism of Sodium-coupled Substrate Uptake by LeuT
Elia Zomot et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
The Second Sodium Site in the Dopamine Transporter Controls Cation Permeation and Is Regulated by Chloride
Lars Borre et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters
Aravind Penmatsa et al.
JOURNAL OF PHYSIOLOGY-LONDON (2014)
Conformational dynamics of ligand-dependent alternating access in LeuT
Kelli Kazmier et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
Conformational cycle and ion-coupling mechanism of the Na+/hydantoin transporter Mhp1
Kelli Kazmier et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Complete Mapping of Substrate Translocation Highlights the Role of LeuT N-terminal Segment in Regulating Transport Cycle
Mary Hongying Cheng et al.
PLOS COMPUTATIONAL BIOLOGY (2014)
NbIT - A New Information Theory-Based Analysis of Allosteric Mechanisms Reveals Residues that Underlie Function in the Leucine Transporter LeuT
Michael V. LeVine et al.
PLOS COMPUTATIONAL BIOLOGY (2014)
Coupled Global and Local Changes Direct Substrate Translocation by Neurotransmitter-Sodium Symporter Ortholog LeuT
Mary Hongying Cheng et al.
BIOPHYSICAL JOURNAL (2013)
The cost of living in the membrane: A case study of hydrophobic mismatch for the multi-segment protein LeuT
Sayan Mondal et al.
CHEMISTRY AND PHYSICS OF LIPIDS (2013)
Simulations of Anionic Lipid Membranes: Development of Interaction-Specific Ion Parameters and Validation Using NMR Data
Richard M. Venable et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2013)
The Membrane Protein LeuT in Micellar Systems: Aggregation Dynamics and Detergent Binding to the S2 Site
George Khelashvili et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
X-ray structure of dopamine transporter elucidates antidepressant mechanism
Aravind Penmatsa et al.
NATURE (2013)
Ligand Induced Conformational Changes of the Human Serotonin Transporter Revealed by Molecular Dynamics Simulations
Heidi Koldso et al.
PLOS ONE (2013)
Transient formation of water-conducting states in membrane transporters
Jing Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Chloride binding site of neurotransmitter sodium symporters
Adriana K. Kantcheva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Mutational Analysis of the High-Affinity Zinc Binding Site Validates a Refined Human Dopamine Transporter Homology Model
Thomas Stockner et al.
PLOS COMPUTATIONAL BIOLOGY (2013)
The Molecular Mechanism of Ion-Dependent Gating in Secondary Transporters
Chunfeng Zhao et al.
PLOS COMPUTATIONAL BIOLOGY (2013)
Ion-Controlled Conformational Dynamics in the Outward-Open Transition from an Occluded State of LeuT
Chunfeng Zhao et al.
BIOPHYSICAL JOURNAL (2012)
The solute carrier 6 family of transporters
Stefan Broeer et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Insights into transport mechanism from LeuT engineered to transport tryptophan
Chayne L. Piscitelli et al.
EMBO JOURNAL (2012)
Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue
Hui Wang et al.
EMBO REPORTS (2012)
Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone φ, ψ and Side-Chain χ1 and χ2 Dihedral Angles
Robert B. Best et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2012)
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
Harini Krishnamurthy et al.
NATURE (2012)
Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context
Hui Wang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Experimental conditions can obscure the second high-affinity site in LeuT
Matthias Quick et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
The Role of Local Hydration and Hydrogen-Bonding Dynamics in Ion and Solute Release from Ion-Coupled Secondary Transporters
Chunfeng Zhao et al.
BIOCHEMISTRY (2011)
Reconstructing a Chloride-binding Site in a Bacterial Neurotransmitter Transporter Homologue
Sotiria Tavoulari et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKa Predictions
Mats H. M. Olsson et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2011)
Molecular Simulations of Dodecyl-β-maltoside Micelles in Water: Influence of the Headgroup Conformation and Force Field Parameters
Stephane Abel et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2011)
Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue
Yongfang Zhao et al.
NATURE (2011)
The Substrate-Driven Transition to an Inward-Facing Conformation in the Functional Mechanism of the Dopamine Transporter
Jufang Shan et al.
PLOS ONE (2011)
Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types
Jeffery B. Klauda et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2010)
Single-molecule dynamics of gating in a neurotransmitter transporter homologue
Yongfang Zhao et al.
NATURE (2010)
Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site
Chayne L. Piscitelli et al.
NATURE (2010)
Substrate-dependent proton antiport in neurotransmitter:sodium symporters
Yongfang Zhao et al.
NATURE CHEMICAL BIOLOGY (2010)
Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter: sodium symporters
Derek P. Claxton et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Modeling and Dynamics of the Inward-Facing State of a Na+/Cl- Dependent Neurotransmitter Transporter Homologue
Saher Afshan Shaikh et al.
PLOS COMPUTATIONAL BIOLOGY (2010)
Ion-Releasing State of a Secondary Membrane Transporter
Jing Li et al.
BIOPHYSICAL JOURNAL (2009)
CHARMM-GUI Membrane Builder for Mixed Bilayers and Its Application to Yeast Membranes
Sunhwan Jo et al.
BIOPHYSICAL JOURNAL (2009)
ACEMD: Accelerating Biomolecular Dynamics in the Microsecond Time Scale
M. J. Harvey et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2009)
A Closer Look at Amphetamine-Induced Reverse Transport and Trafficking of the Dopamine and Norepinephrine Transporters
S. D. Robertson et al.
MOLECULAR NEUROBIOLOGY (2009)
A Juxtamembrane Mutation in the N Terminus of the Dopamine Transporter Induces Preference for an Inward-Facing Conformation
Bipasha Guptaroy et al.
MOLECULAR PHARMACOLOGY (2009)
Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation
Matthias Quick et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Substrate binding and formation of an occluded state in the leucine transporter
Leyla Celik et al.
BIOPHYSICAL JOURNAL (2008)
Sodium-coupled neurotransmitter transporters
Baruch I. Kanner et al.
CHEMICAL REVIEWS (2008)
Anton, a special-purpose machine for molecular dynamics simulation
David E. Shaw et al.
COMMUNICATIONS OF THE ACM (2008)
An intracellular interaction network regulates conformational transitions in the dopamine transporter
Julie Kniazeff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The mechanism of a neurotransmitter:sodium symporter -: Inward release of Na+ and substrate is triggered by substrate in a second binding site
Lei Shi et al.
MOLECULAR CELL (2008)
The binding sites for cocaine and dopamine in the dopamine transporter overlap
Thijs Beuming et al.
NATURE NEUROSCIENCE (2008)
A Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation
Satinder K. Singh et al.
SCIENCE (2008)
Mechanism of chloride interaction with neurotransmitter: sodium symporters
Elia Zomot et al.
NATURE (2007)
Cheerful news for antidepressant research
Simon Hadlington
CHEMISTRY WORLD (2007)
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
Satinder K. Singh et al.
NATURE (2007)
Monitoring the function of membrane transport proteins in detergent-solubilized form
Matthias Quick et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Scalable molecular dynamics with NAMD
JC Phillips et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2005)
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters
A Yamashita et al.
NATURE (2005)
Mechanisms of neurotransmitter release by amphetamines: A review
D Sulzer et al.
PROGRESS IN NEUROBIOLOGY (2005)
Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6
NH Chen et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)
Plasma membrane monoamine transporters: Structure, regulation and function
GE Torres et al.
NATURE REVIEWS NEUROSCIENCE (2003)