Journal
TRANSPLANTATION REVIEWS
Volume 36, Issue 3, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.trre.2022.100707
Keywords
Delayed graft function; Kidney transplantation; Combined kidney-solid organ transplantation; Graft survival; Patient survival
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Kidney delayed graft function (K-DGF) is a common complication and associated with adverse outcomes. K-DGF in combined kidney-solid organ transplantation is understudied. Different transplant types have different rates of K-DGF occurrence, and specific risk factors may be more relevant to certain types of transplantation.
Kidney delayed graft function (K-DGF) is a common post-kidney transplant complication associated with adverse outcomes. With continued advances in solid organ transplantation (SOT), combined kidney-solid organ trans-plantation (CKSOT) is an ever-growing transplant option for patients with advanced kidney disease in the setting of concurrent solid organ failure. K-DGF in this setting is understudied. In this review, we aimed to abridge the representative literature on K-DGF in CKSOT. K-DGF occurs at different rates across combined and sequential kidney-solid organ transplantation (SKSOT), in simultaneous-pancreas kidney (SPK) transplant (8-23%), simultaneous heart-kidney (SHK) transplant (27-37%), simultaneous-liver kidney (SLiK) transplant (16-49%), and kidney after thoracic (13.6-19.2%) and abdominal (13.6-25%) transplantation. Though many K-DGF risk factors span across various subtypes of combined KSOT, some effect particular transplant types more specifically and may be modifiable to reduce K-DGF incidence. While more studies are needed to prevent and manage K-DGF in combined kidney-solid organ transplantation, we hope our review will provide context of this disease and spur further inquiry.
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