Journal
TOXINS
Volume 14, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/toxins14050315
Keywords
Fusarium mycotoxins; mycotoxin mitigation; yeast cell wall extract; postbiotic yeast cell wall-based blend; poultry broilers; EPEF
Categories
Funding
- Alltech, Inc., Nicholasville, KY, USA [19-E-12166]
Ask authors/readers for more resources
The yeast cell wall extract (YCWE) and post-biotic yeast cell wall-based blend (PYCW) were found to alleviate the negative effects of multiple toxins on commercial broilers.
Yeast cell wall-based preparations have shown efficacy against Aspergillus-based toxins but have lower impact against type-B trichothecenes. Presently, we investigated a combination of deoxynivalenol (DON), T-2 toxin (T2) and zearalenone (ZEA), and the effect of a yeast cell wall extract (YCWE) and a post-biotic yeast cell wall-based blend (PYCW) with the objectives of preventing mycotoxins' negative effects in commercial broilers. A total of 720 one-day-old male Cobb broilers were randomly allocated to: (1) control diet, (aflatoxins 6 mu g/kg; cyclopiazonic acid 15 mu g/kg; fusaric acid 25 mu g/kg; fumonisin B1 310 mu g/kg); (2) Diet1 + 0.2% YCWE; (3) Diet1 + 0.2% PYCW; (4) Contaminated diet (3.0 mg/kg DON; 2.17 mg/kg 3-acetyldeoxynivalenol; 104 g/kg T2; 79 g/kg ZEA); (5) Diet4 + 0.2% YCWE; and (6) Diet4 + 0.2% PYCW. Naturally contaminated diets adversely affected performance, serum biochemistry, liver function, immune response, altered cecal SCFA goblet cell count and architecture of intestinal villi. These adverse effects were reduced in birds fed PYCW and to a lesser extent YCWE, indicating protection against toxic assault. PYCW yielded better production performance and stimulated liver function, with higher response to NDV and IBV vaccination. Furthermore, mycotoxins were found to affect production outputs when evaluated with the European poultry production efficiency factor compared to control or YCWE and PYCW supplemented treatments. Taken together, YCWE, when complemented with nutritional add-ons (PYCW), could potentiate the remediation of the negative effects from a multi mycotoxins dietary challenge in broiler birds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available