4.7 Article

Cytotoxicity of Venoms and Cytotoxins from Asiatic Cobras (Naja kaouthia, Naja sumatrana, Naja atra) and Neutralization by Antivenoms from Thailand, Vietnam, and Taiwan

Related references

Note: Only part of the references are listed.
Article Parasitology

Varespladib (LY315920) rescued mice from fatal neurotoxicity caused by venoms of five major Asiatic kraits (Bungarus spp.) in an experimental envenoming and rescue model

Choo Hock Tan et al.

Summary: This study investigated the efficacy of varespladib, a small molecule PLA(2) inhibitor, in alleviating the neurotoxicity caused by Asiatic kraits (Bungarus spp.), suggesting its potential use as an emergency drug for prevention or rescue from acute neurotoxic envenoming.

ACTA TROPICA (2022)

Article Food Science & Technology

A Neurotoxic Snake Venom without Phospholipase A2: Proteomics and Cross-Neutralization of the Venom from Senegalese Cobra, Naja senegalensis (Subgenus: Uraeus)

Kin Ying Wong et al.

Summary: The Senegalese cobra, Naja senegalensis, has a venom composition dominated by three-finger toxins, including cardiotoxin/cytotoxin and alpha-neurotoxins. Unlike other cobra species, the venom of N. senegalensis does not contain phospholipase A(2), making it unique. Although highly lethal, the efficacy of existing antivenom in neutralizing the venom's effects is limited, suggesting a need for further improvement in treatment strategies for cobra bite envenomation in Africa.

TOXINS (2021)

Article Immunology

In Vitro Tests for Assessing the Neutralizing Ability of Snake Antivenoms: Toward the 3Rs Principles

Jose Maria Gutierrez et al.

Summary: There is an urgent need to enhance the implementation of the 3Rs principle in the use of experimental animals in toxinological research and in the assessment of the neutralizing efficacy of snake antivenoms due to the inherent complexity of snake venoms. The state of the art in this field includes correlations between in vivo toxicity tests and in vitro surrogate assays, with potential new in vitro alternatives and 'humane' experimental designs expected to emerge in the future.

FRONTIERS IN IMMUNOLOGY (2021)

Article Infectious Diseases

Echis carinatus snake venom metalloprotease-induced toxicities in mice: Therapeutic intervention by a repurposed drug, Tetraethyl thiuram disulfide (Disulfiram)

Gotravalli Rudresha et al.

Summary: This study reveals that the metalloproteases in Echis carinatus venom are responsible for NETosis and tissue necrosis, and the use of the zinc-specific chelator TTD can inhibit this toxic effect and provide protection against severe tissue necrosis caused by snakebite.

PLOS NEGLECTED TROPICAL DISEASES (2021)

Article Biochemistry & Molecular Biology

Proteomics and neutralization of Bungarus multicinctus (Many-banded Krait) venom: Intra-specific comparisons between specimens from China and Taiwan

Angeline Mei Feng Oh et al.

Summary: The study analyzed the venom proteomes of Many-banded Krait specimens from China and Taiwan, finding similarities in toxin families. Antivenom products from both regions varied in their effectiveness against the venom, with the Chinese-produced BMMAV showing higher potency.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY (2021)

Article Medicine, General & Internal

Naja atra venom-spit ophthalmia in Taiwan: An epidemiological survey from 1990 to 2016

Tsung-Han Tsai et al.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION (2020)

Review Pharmacology & Pharmacy

Causes and Consequences of Snake Venom Variation

Nicholas R. Casewell et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

Article Biochemistry & Molecular Biology

Quantitative proteomics of Naja annulifera (sub-Saharan snouted cobra) venom and neutralization activities of two antivenoms in Africa

Kae Yi Tan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Pharmacology & Pharmacy

Cytotoxin 1 from Naja atra Cantor venom induced necroptosis of leukemia cells

Yamin Liu et al.

TOXICON (2019)

Article Toxicology

Naja atra snakebite in Taiwan

Yan-Chiao Mao et al.

CLINICAL TOXICOLOGY (2018)

Article Health Care Sciences & Services

Long-term health complications following snake envenoming

Subashini Jayawardana et al.

JOURNAL OF MULTIDISCIPLINARY HEALTHCARE (2018)

Article Infectious Diseases

Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease?

Andreas H. Laustsen et al.

PLOS NEGLECTED TROPICAL DISEASES (2017)

Article Medicine, General & Internal

Snakebite envenoming

José María Gutiérrez et al.

Nature Reviews Disease Primers (2017)

Article Integrative & Complementary Medicine

Cytotoxic activity of NN-32 toxin from Indian spectacled cobra venom on human breast cancer cell lines

Saurabh S. Attarde et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)

Article Public, Environmental & Occupational Health

Venom and Purified Toxins of the Spectacled Cobra (Naja naja) from Pakistan: Insights into Toxicity and Antivenom Neutralization

Kin Ying Wong et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2016)

Article Biochemical Research Methods

Unveiling the elusive and exotic: Venomics of the Malayan blue coral snake (Calliophis bivirgata flaviceps)

Choo Hock Tan et al.

JOURNAL OF PROTEOMICS (2016)

Article Ophthalmology

Ophthalmia Due to Spitting Cobra Venom in an Urban Setting - A Report of Three Cases

Leslie Jonathan Ang et al.

MIDDLE EAST AFRICAN JOURNAL OF OPHTHALMOLOGY (2014)

Review Infectious Diseases

Neurotoxicity in Snakebite-The Limits of Our Knowledge

Udaya K. Ranawaka et al.

PLOS NEGLECTED TROPICAL DISEASES (2013)

Article Toxicology

Wound infections secondary to snakebite in central Taiwan

Li-Wen Huang et al.

JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES (2012)

Article Multidisciplinary Sciences

Snake Cytotoxins Bind to Membranes via Interactions with Phosphatidylserine Head Groups of Lipids

Anastasia G. Konshina et al.

PLOS ONE (2011)

Article Pharmacology & Pharmacy

Validation of a cell-based assay to differentiate between the cytotoxic effects of elapid snake venoms

Yasmean Kalam et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2011)

Article Biochemical Research Methods

Jalview Version 2-a multiple sequence alignment editor and analysis workbench

Andrew M. Waterhouse et al.

BIOINFORMATICS (2009)

Article Biochemistry & Molecular Biology

Interaction of three-finger toxins with phospholipid membranes: comparison of S- and P-type cytotoxins

PV Dubovskii et al.

BIOCHEMICAL JOURNAL (2005)

Article Medicine, General & Internal

A study of Thai Cobra (Naja kaouthia) bites in Thailand

N Wongtongkam et al.

MILITARY MEDICINE (2005)

Article Biochemical Research Methods

MUSCLE: a multiple sequence alignment method with reduced time and space complexity

RC Edgar

BMC BIOINFORMATICS (2004)

Article Pharmacology & Pharmacy

Molecular moulds with multiple missions: Functional sites in three-finger toxins

RM Kini

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2002)

Article Biochemistry & Molecular Biology

Molecular determinants by which a long chain toxin from snake venom interacts with the neuronal α7-nicotinic acetylcholine receptor

S Antil-Delbeke et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)