Journal
CANCER LETTERS
Volume 357, Issue 2, Pages 549-556Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2014.12.008
Keywords
Case-control study; Genetic polymorphism; Tobacco-independent; Nonsmoker; Head and neck cancer risk
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Funding
- NCI/NIH [K07CA137140, P50CA097190]
- Howard Hughes Medical Fellows Program
- NIH [UL1 RR024153]
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EGFR polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60 EGFR single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk. EGER intronic SNPs rs12535536, rs2075110, rsl 253871, rs845561 and rs6970262 and synonymous SNP rs2072454 were associated with HNSCC risk among all subjects (p < 0.05). SNPs rs12538371, rs845561, and rs6970262 were significantly associated with HNSCC risk (p < 0.05) among never tobacco users. We identified EGFR variants that likely modify risk for HNSCC including three variants that contribute to tobacco-independent risk. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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