Journal
POLYMERS
Volume 14, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/polym14102118
Keywords
DNA-DNA junction; G-quadruplex; i-motif; recombination
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Funding
- Russian Foundation for Basic Research [19-015-00024]
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This study reports the spontaneous formation of DNA-DNA junctions in solution without the involvement of proteins, visualized using atomic force microscopy. The positions of synapsis match with potential G-quadruplex (G4) sites, and these conjugates exhibit an affinity for G4 antibodies. Molecular modeling was employed to elucidate the possible structures of G4/IM-synaptic complexes, indicating a novel role of intermolecular noncanonical structures in chromatin architecture and genomic rearrangement.
We report the spontaneous formation of DNA-DNA junctions in solution in the absence of proteins visualised using atomic force microscopy. The synapsis position fits with potential G-quadruplex (G4) sites. In contrast to the Holliday structure, these conjugates have an affinity for G4 antibodies. Molecular modelling was used to elucidate the possible G4/IM-synaptic complex structures. Our results indicate a new role of the intermolecular noncanonical structures in chromatin architecture and genomic rearrangement.
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