Novel Trends into the Development of Natural Hydroxyapatite-Based Polymeric Composites for Bone Tissue Engineering

Article Materials Science, Ceramics

Homology of selenium (Se) and tellurium (Te) endow the functional similarity of Se-doped and Te-doped mesoporous bioactive glass nanoparticles in bone tissue engineering

Ying Zhang et al.

Summary: In this study, Se-doped and Te-doped MBG nanoparticles were successfully synthesized, demonstrating similar structure and properties as expected, such as drug sustained release, anticancer, and antibacterial properties.

CERAMICS INTERNATIONAL (2022)

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Article Materials Science, Multidisciplinary

Printable gelatin, alginate and boron nitride nanotubes hydrogel-based ink for 3D bioprinting and tissue engineering applications

Akesh B. Kakarla et al.

Summary: A novel printable hydrogel-based ink solution comprised of gelatin-alginate (GA) reinforced by boron nitride nanotubes (BNNTs) was developed for 3D bioprinting and tissue engineering applications. The research showed that increasing the concentration of BNNTs improved printability and printing accuracy, but also affected the swelling rate of the scaffold. The study suggests that BNNTs reinforced GA scaffold could be a potential ink solution for tissue engineering applications through 3D bioprinting processes.

MATERIALS & DESIGN (2022)

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Article Engineering, Biomedical

Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment

Luyu Wang et al.

Summary: The study demonstrates the therapeutic effect of using injectable hyaluronic acid hydrogel encapsulated with bone mesenchymal stem cells and nerve growth factors for traumatic brain injury. The hydrogel loaded with BMSC and NGF improved neurological function recovery by promoting neurotrophic factors release and neuroinflammation regulation, accelerating the repair process.

MATERIALS TODAY BIO (2022)

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Review Materials Science, Ceramics

A review on mechanical and In-vitro studies of polymer reinforced bioactive glass-scaffolds and their fabrication techniques

Satish Jain et al.

Summary: Extensive research has been conducted on bioactive scaffolds as replacement material in bone-tissue engineering. This review focuses on the mechanical behavior of polymer-bioactive glass scaffolds, revealing the need for improved strength. The impact of ceramic filler content on the in-vitro bioactivity and biodegradability of the scaffold is discussed, along with the rationale and approach for fabricating 3-D scaffolds with well-distributed and interconnected pores.

CERAMICS INTERNATIONAL (2022)

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Article Engineering, Environmental

Cryogenically 3D printed biomimetic scaffolds containing decellularized small intestinal submucosa and Sr2+/Fe3+ co-substituted hydroxyapatite for bone tissue engineering

Liang Yang et al.

Summary: This study highlights the potential of a novel biomimetic scaffold composed of decellularized small intestinal submucosa matrix (SIS-ECM) and Sr2+/Fe3+ co-substituted hydroxyapatite (SrFeHA) for inducing bone healing. The scaffold possesses favorable physico-chemical properties and shows promising results in immunoregulation, angiogenesis, osteogenesis, and biomineralization. Additionally, a new pathway related to enhanced angiogenesis was identified. This research provides new insights into the mechanisms of bioactive SrFeHA components and offers a promising alternative for future bone tissue engineering.

CHEMICAL ENGINEERING JOURNAL (2022)

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Review Chemistry, Multidisciplinary

PCL-PEG copolymer based injectable thermosensitive hydrogels

Mithun Rajendra Dethe et al.

Summary: Stimuli-responsive hydrogels have been extensively studied in biomedical applications due to their biodegradability and biocompatibility. The emergence of in situ stimuli-responsive hydrogels is the result of advancements in synthetic chemistry and materials science. The copolymer PCL-PEG, recognized by the FDA, can form thermosensitive injectable hydrogels that exhibit rapid and reversible gelation behavior.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Engineering, Biomedical

Coaxial electrospinning of composite mats comprised of core/shell poly(methyl methacrylate)/silk fibroin fibers for tissue engineering applications

Deniz Atila et al.

Summary: This study optimized the electrospinning process of core/shell poly(methyl methacrylate)/silk fibroin fibers to mimic the extracellular matrix and induce tissue regeneration. By adjusting the morphology and chemical properties of the fibers, the water contact angle and porosity of the mats could be altered. The core/shell fibers exhibited intermediate mechanical properties, porous structure, and fine morphology. These fibers promoted the attachment and proliferation of dental pulp stem cells.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2022)

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Article Engineering, Biomedical

Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering

Xu Xue et al.

Summary: Bone tissue engineering provides promising tools for the treatment of bone-related diseases using biomimetic hydrogels. This article discusses the fabrication of biomimetic hydrogels using thermal sensitive polymers, mineral ions, chemically triggered agents, photo crosslinking initiators, and enzyme triggers. These hydrogels accelerate bone regeneration and the article also highlights key factors influencing therapeutic effects.

BIOACTIVE MATERIALS (2022)

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Article

Polymer/metal composite 3D porous bone tissue engineering scaffolds fabricated by additive manufacturing techniques: A review

Meysam Mohammadi Zerankeshi et al.

Bioprinting (2022)

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Proceedings Paper Materials Science, Multidisciplinary

Corrosion behavior of AZ31 magnesium alloys coated with PMMA/HA as biodegradable implants

Zainab F. Al-Sherify et al.

Summary: The rapid corrosion rates of magnesium alloys limit their use as biodegradable implants. An AZ31 magnesium alloy was coated with a polymethylmethacrylate (PMMA)/hydroxyapatite (HA) composite coating using a spin coating process. The coating characteristics and corrosion resistance were evaluated, and it was found that adding hydroxyapatite particles to the PMMA polymer significantly reduces the corrosion rate.

MATERIALS TODAY-PROCEEDINGS (2022)

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Article Engineering, Industrial

Additive manufacturing of biodegradable iron-based particle reinforced polylactic acid composite scaffolds for tissue engineering

Dayue Jiang et al.

Summary: The study showed that PLA-based composite scaffolds with optimized printing parameters have accurate pore dimensions and evenly distributed iron-based powders, with lower thermal expansion coefficients, enhanced mechanical properties, reduced surface roughness, and superior degradation resistance, wetting behavior, and cytocompatibility. These results demonstrate the potential of PLA/iron scaffolds in bone tissue engineering applications.

JOURNAL OF MATERIALS PROCESSING TECHNOLOGY (2021)

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Article

A review of multi-functional ceramic nanoparticles in 3D printed bone tissue engineering

Niyou Wang et al.

Bioprinting (2021)

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Article Materials Science, Multidisciplinary

The effect of wash treatment on the mechanical properties and energy absorption potential of a 3D printed polymethyl methacrylate (PMMA)

Alexander Bardelcik et al.

Summary: Different wash treatments were applied to 3D-printed Polymethyl Methacrylate resin samples, with detergent wash resulting in increased toughness. Finite element simulations showed that HP5 + D and As-Printed + D wash conditions have potential applications in energy absorbing octet-truss lattice structures.

MATERIALS TODAY COMMUNICATIONS (2021)

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Article Materials Science, Ceramics

Effect of pH on the properties of eggshell-derived hydroxyapatite bioceramic synthesized by wet chemical method assisted by microwave irradiation

Kian Wei Goh et al.

Summary: In this study, eggshell-derived hydroxyapatite (HA) powder was successfully synthesized using a simple wet chemical method assisted by microwave irradiation. Different pH values were investigated to reveal their impact on the properties of HA particles. The study demonstrated that pH plays a crucial role in altering the morphology and size of HA particles.

CERAMICS INTERNATIONAL (2021)

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Article Materials Science, Ceramics

Preparation and application of hydroxyapatite extracted from fish scale waste using deep eutectic solvents

Yanhong Liu et al.

Summary: This study proposed a green and environmentally-friendly method to extract hydroxyapatite (HAP) from crucian carp scales, achieving a extraction rate of 40.58%. The extracted HAP displayed high purity, excellent thermal stability, and good adsorption capacity for metal ions like lead and copper.

CERAMICS INTERNATIONAL (2021)

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Review Materials Science, Ceramics

A comprehensive review on the preparation and application of calcium hydroxyapatite: A special focus on atomic doping methods for bone tissue engineering

Sikta Panda et al.

Summary: Hydroxyapatite has been widely used in bone tissue engineering due to its similarity to human bone, with the possibility of enhancing its properties by replacing calcium with other dopants. The review discusses various coating agents and methods for HAP, as well as different doping materials, effects, and applications in medical procedures. Research articles are analyzed to provide a detailed overview of the topic.

CERAMICS INTERNATIONAL (2021)

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Article Engineering, Biomedical

CNT and rGO reinforced PMMA based bone cement for fixation of load bearing implants: Mechanical property and biological response

F. Pahlevanzadeh et al.

Summary: A novel bioactive polymethyl methacrylate-hardystonite bone cement reinforced with carbon nanotube and reduced graphene oxide was synthesized to improve mechanical properties and enhance osteoblast viability. Results showed that the rGO reinforced cement exhibited better mechanical properties and supported MG63 cell attachment, making it a suitable bone cement for load-bearing implants.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2021)

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Review Materials Science, Biomaterials

Ultrathin polymer fibers hybridized with bioactive ceramics: A review on fundamental pathways of electrospinning towards bone regeneration

Filipe V. Ferreira et al.

Summary: The combination of electrospun ultrathin polymer fibers with bioactive ceramics presents unique advantages in biomedical applications, particularly in bone tissue regeneration. Despite the lack of a comprehensive review on this topic, recent developments focusing on the preparation of bioactive ceramics, bone anatomy and mechanical properties, and the relationships of electrospun fibers are discussed in detail. Challenges and future perspectives in developing next-generation hybrid materials for bone tissue engineering are highlighted.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Multidisciplinary

Polymer architecture as key to unprecedented high-resolution 3D-printing performance: The case of biodegradable hexa-functional telechelic urethane-based poly-ε-caprolactone

Aysu Arslan et al.

Summary: Two-photon polymerization (2PP) is a high-resolution 3D-printing technology with diverse applications, including tissue engineering (TE). However, the limited number of biodegradable materials supporting the required level of spatial resolution presents a major bottleneck for 2PP in the TE field.

MATERIALS TODAY (2021)

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Article Clinical Neurology

A novel nano-hydroxyapatite/synthetic polymer/bone morphogenetic protein-2 composite for efficient bone regeneration

Zeynep Bal et al.

Summary: The novel composite material of nHAp/PLA-PEG demonstrated efficient bone regeneration with low-dose BMP-2. ELISA results showed sustained release of BMP-2 up to day 21, with 91.6% of specimens in both the low- and high-dose groups achieving solid fusion according to μCT and manual palpation test, while none in the control group achieved bony fusion.

SPINE JOURNAL (2021)

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Review Biochemistry & Molecular Biology

Hyaluronic acid hydrogels, as a biological macromolecule-based platform for stem cells delivery and their fate control: A review

Yu Fang et al.

Summary: Stem cell-based therapies have great potential for organ repair, but actual outcomes are disappointing. Hyaluronic acid-based hydrogels show promise for stem cell delivery, but differentiation process is easily influenced. Hyaluronic acid holds broad prospects in stem cell delivery and fate control.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biology

Spectral characterization of hydroxyapatite extracted from Black Sumatra and Fighting cock bone samples: A comparative analysis

K. C. Vinoth Kumar et al.

Summary: In this study, natural hydroxyapatite was extracted from different bone samples through thermal calcination process and compared for their crystalline nature, functional groups and morphological characteristics. The results showed that hydroxyapatite from waste bones of fighting cock had higher crystallinity and smaller grain size compared to Black Sumatra bones.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Chemistry, Multidisciplinary

Nano-Hydroxyapatite Derived from Biogenic and Bioinspired Calcium Carbonates: Synthesis and In Vitro Bioactivity

Francesca Cestari et al.

Summary: The study investigated the synthesis of bioactive calcium phosphates using different biogenic calcium carbonates and their effects on cell adhesion and proliferation. The phase composition and densification of the sintered materials were found to be influenced by the source of CaCO3 and sintering temperature. Preliminary in vitro tests showed good cell adhesion and proliferation, with variations observed among different materials.

NANOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

The role of natural polymers in bone tissue engineering

Linqi Guo et al.

Summary: Bone is a dynamic self-healing organ with continuous remodeling, but surgical interventions and bone substitutes are needed for repairing large traumatic injuries. Bone tissue engineering aims to repair and regenerate tissues, with natural polymers like collagen and chitosan widely used in the field.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Materials Science, Multidisciplinary

Preparation and biocompatibility studies of Collagen/Hyaluronic Acid/ Oligomeric proanthocyanidins composites

Shanji Li et al.

Summary: This study aimed to use natural polymers and natural crosslinkers to design and test a Collagen/HA/OPC scaffold for chondrogenesis, showing excellent biocompatibility and potential applications in cartilage or bone restoration. Results revealed the potential of these bioactive scaffolds for different applications with various additives.

MATERIALS CHEMISTRY AND PHYSICS (2021)

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Article Materials Science, Biomaterials

3D-printed alginate-hydroxyapatite aerogel scaffolds for bone tissue engineering

Ana Iglesias-Mejuto et al.

Summary: 3D printing technology plays a vital role in the manufacturing of functional structures with customized geometries and compositions, especially in the field of tissue engineering.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Biomaterials

3D-printed Mg-incorporated PCL-based scaffolds: A promising approach for bone healing

Qiangsheng Dong et al.

Summary: 3D-printed Mg/PCL composite scaffolds, with 3 wt% Mg, showed enhanced osteogenesis and biomineralization, promoting bone repairing ability both in vitro and in vivo. These scaffolds exhibited improved mechanical properties, good biocompatibility, and enhanced osteogenic and angiogenic activities, indicating promising strategies for bone healing application.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Chemistry, Medicinal

Poly ethylene glycol (PEG)-Related controllable and sustainable antidiabetic drug delivery systems

Yupeng Fu et al.

Summary: Polyethylene glycol (PEG) is a promising material for drug delivery due to its unique features including hydrophilicity, biocompatibility, and biodegradability；PEG molecules can protect delivery systems, reduce immunogenicity, and avoid undesirable enzymolysis；PEG has been widely applied in various delivery systems such as micelles, vesicles, nanoparticles, and hydrogels.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Polymer Science

Advanced polymer-based composites and structures for biomedical applications

Zhengchao Guo et al.

Summary: This study summarized the advancements in polymer-based composites in terms of their properties, structure, and fabrication techniques for biomedical applications, including bioactive and non-bioactive materials, as well as scaffold fabrication methods.

EUROPEAN POLYMER JOURNAL (2021)

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Article Chemistry, Multidisciplinary

Promoting bone regeneration by 3D-printed poly(glycolic acid)/hydroxyapatite composite scaffolds

Taegyun Yeo et al.

Summary: 3D-printed PGA/HAp scaffolds demonstrate significant potential for promoting bone tissue regeneration with higher compressive strength and biodegradability. Clinical experiments show a higher rate of bone regeneration and bone density.

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2021)

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Article Engineering, Biomedical

Mechanical and morphological characterization of PMMA/bone composites in human femoral heads

Amelie Sas et al.

Summary: This study aimed to investigate the morphological and quasi-static compressive properties of proximal femoral bone-cement composites, finding that the composite specimens exhibited higher compressive modulus and ultimate strength compared to bone only specimens. The results suggest that the properties of bone-cement composites cannot be simply generalized to different anatomical sites, and highlight the importance of considering site-specific differences in bone density and trabecular alignment.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2021)

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Review Polymer Science

Collagen blended with natural polymers: Recent advances and trends

Alina Sionkowska

Summary: This review provides a report on recent advances in the field of research on collagen blends with other natural polymers, discussing the potential applications of such blends in the biomedical field and cosmetic preparations.

PROGRESS IN POLYMER SCIENCE (2021)

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Article Green & Sustainable Science & Technology

Recent advances in biopolymeric composite materials: Future sustainability of bone-implant

Bankole Oladapo et al.

Summary: This research summary focuses on the outcome of a critical review on the medical applications of poly-ether-ether-ketone (PEEK) and its composite materials, including 3D printing and interface healing process. Utilizing the Scopus database and Google search, peer-reviewed papers from the past twelve years were examined. The findings could enhance sustainability and understanding of osteointegration models for PEEK and its composites in the medical and scientific community.

RENEWABLE & SUSTAINABLE ENERGY REVIEWS (2021)

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Review Chemistry, Applied

Synthesis, biological and environmental applications of hydroxyapatite and its composites with organic and inorganic coatings

Thivaharan Varadavenkatesan et al.

Summary: The demand for biomaterials is increasing, with HAP and its composites showing ideal characteristics for diverse biomedical applications. The use of low-cost biowastes for synthesis aids sustainability, while the properties of the fabricated end-product depend on the type of precursor and synthesis protocols used.

PROGRESS IN ORGANIC COATINGS (2021)

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Review Crystallography

Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

Hui Shi et al.

Summary: Hydroxyapatite is widely used in bone tissue engineering for its bioactivity and biocompatibility, with researchers exploring ways to improve its physical properties and biological functions. Functionalized HA has been prepared using methods such as ion doping and surface modification, and applications in bone tissue engineering have been discussed in this review. The review provides a general understanding of the development of hydroxyapatite-based materials for researchers.

CRYSTALS (2021)

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Review Cell & Tissue Engineering

Applications of 3D printed bone tissue engineering scaffolds in the stem cell field

Xin Su et al.

Summary: Regenerative medicine was born out of the need for organ and tissue replacement due to shortages, with 3D printed bone tissue engineering scaffolds combined with stem cells offering a solution to large tissue defects and promoting regeneration.

REGENERATIVE THERAPY (2021)

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Article Materials Science, Multidisciplinary

Combining bioresorbable polyesters and bioactive glasses: Orthopedic applications of composite implants and bone tissue engineering scaffolds

Lukas Gritsch et al.

Summary: This overview highlights the fabrication, properties, and applications of bioactive glass-polyester composites in dentistry, craniomaxillofacial surgery, orthopedics, and bone tissue engineering, emphasizing the potential future applications in bone substitutes. Current research focuses mainly on material fabrication and characterization, with less evidence of translational research efforts. Future studies are needed to collect more in vivo and clinical data to enhance understanding of the time-dependent performance of these materials in realistic conditions.

APPLIED MATERIALS TODAY (2021)

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Review Engineering, Biomedical

Poly(lactic-co-glycolic acid)-based composite bone-substitute materials

Duoyi Zhao et al.

Summary: This article comprehensively reviews the research and applications of artificial bone-substitute materials based on PLGA and its composites, discussing their potential and challenges in bone regeneration.

BIOACTIVE MATERIALS (2021)

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Review Polymer Science

Recent advances in natural polymer-based hydroxyapatite scaffolds: Properties and applications

J. Anita Lett et al.

Summary: New materials mimicking natural bone properties are developed for bone defect rehabilitation, along with tissue engineering utilizing life sciences and engineering principles for biological replacements. However, bone grafting treatments have restrictions such as morbidity risks and immune rejection, leading to the exploration of synthetic materials for implantable bones.

EUROPEAN POLYMER JOURNAL (2021)

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Article Materials Science, Multidisciplinary

Collagen-based biomaterials for bone tissue engineering

Youbin Li et al.

Summary: Collagen is an ideal material for bone tissue engineering due to its easy degradation, strong plasticity, and low immunogenicity, but pure collagen alone may not produce satisfactory results. Therefore, biomimetic bone tissue engineering scaffolds are often prepared with other bioactive materials. Research on collagen-based biomimetic bone tissue engineering focuses on collagen acquisition, osteogenesis induction mechanisms, composition of biomimetic materials, and application in bone tissue engineering.

MATERIALS & DESIGN (2021)

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Article Materials Science, Multidisciplinary

Design and manufacturing of 3D high-precision micro-fibrous poly (L-lactic acid) scaffold using melt electrowriting technique for bone tissue engineering

Jie Meng et al.

Summary: This study successfully prints the thermally sensitive polymer PLLA to a high-resolution object using the melt electrowriting technology, and manufactures PLLA scaffolds with adjustable filament diameter and pore size for bone tissue engineering. By investigating the relationships among the rheological behavior, electro-hydrodynamics, and processing parameters, relatively high deposition accuracy and crystallinity of PLLA were achieved. The PLLA scaffold with filament diameter of 40 μm and pore size of 200 μm was evaluated with cells to demonstrate its in vitro potential, marking a milestone for melt electrowriting in designing and manufacturing essential biobased polymers for tissue engineering.

MATERIALS & DESIGN (2021)

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Review Chemistry, Multidisciplinary

Nanotechnology, and scaffold implantation for the effective repair of injured organs: An overview on hard tissue engineering

Parinaz Abdollahiyan et al.

Summary: 3D bioprinting techniques in tissue engineering have shown great potential in constructing hard organs and tissues, such as bone and cartilage. However, the main challenge lies in replicating the complex structures of natural tissues.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Pharmacology & Pharmacy

Influence of chitosan and hydroxyapatite incorporation on properties of electrospun PVA/HA nanofibrous mats for bone tissue regeneration: Nanofibers optimization and in-vitro assessment

Samar A. Salim et al.

Summary: The 3D scaffolds made of PVA/HA nanofiber mats, optimized with chitosan and hydroxyapatite, demonstrated improved biocompatibility and mechanical stability. The different compositions of nanofiber mats showed high cell viability and adhesion in cell evaluation and in vitro experiments.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Review Engineering, Biomedical

Biofabrication of natural hydrogels for cardiac, neural, and bone Tissue engineering Applications

Kamil Elkhoury et al.

Summary: Natural hydrogels are highlighted as promising biomaterials in tissue engineering applications due to their biocompatibility and biodegradability. Innovative biofabrication techniques, such as textile techniques and 3D bioprinting, play a significant role in developing advanced scaffolds for tissue engineering. This review also discusses the emerging applications of biofabricated natural hydrogels in cardiac, neural, and bone tissue engineering.

BIOACTIVE MATERIALS (2021)

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Review Engineering, Biomedical

Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds

Guanyin Zhu et al.

Summary: Bone-tissue defects are a global issue, with autologous and allogeneic bone grafting failing to achieve ideal therapeutic effects. This has led researchers to explore novel bone-regeneration methods, with the development of BTE scaffolds at the forefront. By delving into bone physiology and healing mechanisms, biomimicking and bioinspired BTE scaffolds are making progress.

BIOACTIVE MATERIALS (2021)

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Review Engineering, Biomedical

Bioinspired mineralized collagen scaffolds for bone tissue engineering

Zhengwei Li et al.

Summary: This article thoroughly summarizes the state of the art of mineralized collagen scaffolds (MCSs) as tissue-engineered scaffolds for bone repair, including fabrication methods, critical factors for osteogenesis regulation, and opportunities and challenges for the future. The review discusses current fabrication methods for MCSs to improve their biomimetic physical structures, as well as the physical, biological, and chemical cues as critical factors for regulating the osteogenic feature of MCSs. Opportunities and challenges associated with MCSs as bone tissue-engineered scaffolds are also discussed to point out future directions for building the next generation of MCSs with satisfactorily mimetic structures and appropriate biological characters for bone regeneration.

BIOACTIVE MATERIALS (2021)

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Review Polymer Science

A systematic review of polymer composite in biomedical engineering

Bankole Oladapo et al.

Summary: This review focuses on 3D printing of calcium hydroxyapatite (cHAp) as a composite on poly-ether-ether-ketone (PEEK) scaffolds, highlighting the interactions between PEEK/cHAp interfaces and the biocompatibility of the materials. It discusses the application of cHAp scaffolds in bone tissue engineering and the development of multifunctional cHAp-based systems for advanced therapies.

EUROPEAN POLYMER JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Preparation of microfluidic-based pectin microparticles loaded carbon dots conjugated with BMP-2 embedded in gelatin-elastin-hyaluronic acid hydrogel scaffold for bone tissue engineering application

Alireza Rajabnejadkeleshteri et al.

Summary: The study developed a controlled BMP-2-CDs release system by encapsulating BMP-2-CDs in pectin microparticles using a microfluidic approach, and incorporating them into composite scaffolds made of gelatin, elastin, and hyaluronic acid. The system demonstrated a high controlled delivery capacity for bone regeneration and has promising potential in the field.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Preparation and characterization of polycaprolactone/chitosan-g-polycaprolactone/hydroxyapatite electrospun nanocomposite scaffolds for bone tissue engineering

Iman Shirzaei Sani et al.

Summary: Chitosan and poly (epsilon-caprolactone) were combined to fabricate bone tissue engineering scaffolds with enhanced bioactivity and mechanical properties. The incorporation of chitosan-g-poly (epsilon-caprolactone) significantly decreased fiber diameter and hydroxyapatite nanoparticles enhanced mineralization and degradation of the scaffold. In vitro cytocompatibility assays showed high cell viability and proliferation, indicating the potential use of the microfabricated nanocomposite scaffolds in bone tissue engineering.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Materials Science, Biomaterials

3D printed PCL/β-TCP cross-scale scaffold with high-precision fiber for providing cell growth and forming bones in the pores

Qifan Wang et al.

Summary: A scaffold with a cross-scale structure of PCL/beta-TCP was designed to promote cell growth and osteogenic differentiation on 3D printing scaffolds, significantly enhancing osteogenic performance. Cells can pass through the pores of the scaffold, gradually covering them, which accelerates bone defect repair.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Biomaterials

Biomechanical performances of PCL/HA micro- and macro-porous lattice scaffolds fabricated via laser powder bed fusion for bone tissue engineering

Maria Laura Gatto et al.

Summary: This study aimed to extend knowledge on resorbable PCL/HA scaffolds produced by LPBF technology, exploring the impact of micro and macro structures on bone tissue regeneration. The scaffolds were characterized for structural, mechanical, and biological properties, with findings indicating a strong dependence of scaffold behavior on unit cell geometry and global geometrical features.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Biomaterials

Strontium mineralized silk fibroin porous microcarriers with enhanced osteogenesis as injectable bone tissue engineering vehicles

Jianjun Fang et al.

Summary: This study constructed strontium-functionalized SF microcarriers that showed potential in bone tissue engineering applications by promoting the attachment, proliferation, and secretion of extracellular matrix of BMSCs. The microcarriers with an open interconnected pore can be fabricated by controlling the concentration of SF.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Multidisciplinary

Chitosan-hydroxyapatite-MWCNTs nanocomposite patch for bone tissue engineering applications

Alejandro Gomez Sanchez et al.

Summary: The study examined the properties of chitosan-hydroxyapatite-multiwall carbon nanotube films at various concentrations and found that certain combinations showed superior mechanical properties, conductivity, and biocompatibility, making them suitable for the development of a flexible patch for bone tissue engineering.

MATERIALS TODAY COMMUNICATIONS (2021)

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Review Chemistry, Applied

Extraction Methods, Characterization and Biomedical Applications of Collagen: a Review

Omar El Blidi et al.

Summary: Developing a standard extraction method for all types of collagen from different tissues is challenging due to their extreme diversity. Different methods have their pros and cons, and some have been optimized for easier extraction. Collagen plays a significant role in biomedical applications.

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY (2021)

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Article Materials Science, Ceramics

Effects of surface roughness and texture on the bacterial adhesion on the bearing surface of bio-ceramic joint implants: An in vitro study

Ange Lu et al.

CERAMICS INTERNATIONAL (2020)

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Review Biochemistry & Molecular Biology

The application of hyaluronic acid in bone regeneration

Peisong Zhai et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Engineering, Biomedical

Four-dimensional bioprinting: Current developments and applications in bone tissue engineering

Zhuqing Wan et al.

ACTA BIOMATERIALIA (2020)

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Article Materials Science, Ceramics

Effect of the processing parameters on surface, physico-chemical and mechanical features of bioceramics synthesized from abundant carp fish bones

Andreea Maidaniuc et al.

CERAMICS INTERNATIONAL (2020)

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Article Materials Science, Ceramics

Biocompatibility and drug delivery efficiency of PEG-b-PCL/hydroxyapatite bilayer coatings on Nitinol superelastic alloy

M. R. Etminanfar et al.

CERAMICS INTERNATIONAL (2020)

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Article Biochemistry & Molecular Biology

The toughness chitosan-PVA double network hydrogel based on alkali solution system and hydrogen bonding for tissue engineering applications

Shichao Bi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Biochemistry & Molecular Biology

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

Aziz Eftekhari et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Pharmacology & Pharmacy

Melt electrohydrodynamic 3D printed poly (ε-caprolactone)/polyethylene glycol/roxithromycin scaffold as a potential anti-infective implant in bone repair

Jianfu Bai et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Materials Science, Multidisciplinary

Common biocompatible polymeric materials for tissue engineering and regenerative medicine

Nahideh Asadi et al.

MATERIALS CHEMISTRY AND PHYSICS (2020)

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Article Materials Science, Multidisciplinary

Mechanical properties of natural hydroxyapatite using low cold compaction pressure: Effect of sintering temperature

D. O. Obada et al.

MATERIALS CHEMISTRY AND PHYSICS (2020)

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Article Engineering, Chemical

Improved effect of autoclave processing on size reduction, chemical structure, nutritional, mechanical and in vitro digestibility properties of fish bone powder

Asad Nawaz et al.

ADVANCED POWDER TECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Films of chitosan and natural modified hydroxyapatite as effective UV-protecting, biocompatible and antibacterial wound dressings

Carla S. Cunha et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Chemistry, Physical

Deposition of biphasic calcium phosphate film on laser surface textured Ti-6Al-4V and its effect on different biological properties for orthopedic applications

R. R. Behera et al.

JOURNAL OF ALLOYS AND COMPOUNDS (2020)

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Article Materials Science, Multidisciplinary

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