4.4 Article

Design, synthesis and docking studies of new hydrazinyl-thiazole derivatives as anticancer and antimicrobial agents

Related references

Note: Only part of the references are listed.
Article Immunology

Ceftobiprole Compared With Vancomycin Plus Aztreonam in the Treatment of Acute Bacterial Skin and Skin Structure Infections: Results of a Phase 3, Randomized, Double-blind Trial (TARGET)

J. Scott Overcash et al.

Summary: The study demonstrated that ceftobiprole is noninferior to vancomycin/aztreonam in the treatment of ABSSSIs, showing comparable early clinical response rates and investigator-assessed clinical success at the TOC visit.

CLINICAL INFECTIOUS DISEASES (2021)

Article Biochemistry & Molecular Biology

Eco-friendly sequential one-pot synthesis, molecular docking, and anticancer evaluation of arylidene-hydrazinyl-thiazole derivatives as CDK2 inhibitors

Abeer M. El-Naggar et al.

Summary: This study describes the discovery and development process of a novel potential CDK2 inhibitor. The synthesized compounds showed strong growth inhibition against various cancer cell lines with low toxicity on normal fibroblast cells. One compound exhibited inhibitory effects on cell cycle progression and apoptosis. Molecular docking study identified the structural elements involved in the inhibitory activity and rationalized the structure-activity relationship.

BIOORGANIC CHEMISTRY (2021)

Article Chemistry, Medicinal

Thiazole-Based Thiosemicarbazones: Synthesis, Cytotoxicity Evaluation and Molecular Docking Study

Sobhi M Gomha et al.

Drug Design Development and Therapy (2021)

Article Biochemistry & Molecular Biology

Thiazole-Chalcone Hybrids as Prospective Antitubercular and Antiproliferative Agents: Design, Synthesis, Biological, Molecular Docking Studies and In Silico ADME Evaluation

Ashok Babu Kasetti et al.

Summary: A novel series of thiazole-chalcone hybrids were synthesized and evaluated for their antitubercular and antiproliferative activities. Some compounds exhibited higher activity than standard drugs, showing potential in the treatment of tuberculosis infections and prostate cancer.

MOLECULES (2021)

Article Environmental Sciences

Experimental and computational study of hydrolysis and photolysis of antibiotic ceftriaxone: Degradation kinetics, pathways, and toxicity

Biljana F. Abramovic et al.

Summary: This work investigated the hydrolysis and photolysis of cephalosporin antibiotics with ceftriaxone as a model compound. The results showed that CEF was removed more quickly in ultrapure water compared to natural water. Under UVA-B radiation, CEF removal was more effective, while solar radiation showed limited degradation.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Chemistry, Medicinal

New functionalized 6-thienylpyrimidine-5-carbonitriles as antiproliferative agents against human breast cancer cells

Omaima M. AboulWafa et al.

Summary: 6-Thienylpyrimidine-5-carbonitrile derivatives were synthesized and evaluated for their in vitro antiproliferative activities against human breast cancer cell lines, with some compounds showing good inhibitory activity against both cell lines and the ability to induce apoptosis through various mechanisms.

ARCHIV DER PHARMAZIE (2021)

Article Chemistry, Multidisciplinary

Design, multistep synthesis and in-vitro antimicrobial and antioxidant screening of coumarin clubbed chalcone hybrids through molecular hybridization approach

Sathish Kumar Konidala et al.

Summary: In this study, multiple coumarin clubbed chalcone hybrids were synthesized and evaluated for their antimicrobial and antioxidant activities, revealing certain compounds with potential antimicrobial and antioxidant properties.

ARABIAN JOURNAL OF CHEMISTRY (2021)

Article Gastroenterology & Hepatology

Burden of liver diseases in the world

Sumeet K. Asrani et al.

JOURNAL OF HEPATOLOGY (2019)

Review Microbiology

Bacterial Proteinaceous Compounds With Multiple Activities Toward Cancers and Microbial Infection

Gisele Rodrigues et al.

FRONTIERS IN MICROBIOLOGY (2019)

Review Chemistry, Medicinal

Role of sulphur-heterocycles in medicinal chemistry: An update

Shelly Pathania et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Editorial Material Biochemistry & Molecular Biology

Heterocycles in Medicinal Chemistry

Josef Jampilek

MOLECULES (2019)

Review Chemistry, Multidisciplinary

Peptides with Dual Antimicrobial and Anticancer Activities

Mario R. Felicio et al.

FRONTIERS IN CHEMISTRY (2017)

Article Chemistry, Medicinal

Synthesis, SAR and molecular docking studies of benzo[d]thiazole-hydrazones as potential antibacterial and antifungal agents

Gao-Feng Zha et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

Review Chemistry, Medicinal

Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry

Minghao Feng et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Synthesis, biological evaluation and 3D-QSAR study of novel 4,5-dihydro-1H-pyrazole thiazole derivatives as BRAF(V600E) inhibitors

Meng-Yue Zhao et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2015)

Article Immunology

Isavuconazole: A New Broad-Spectrum Triazole Antifungal Agent

Marisa H. Miceli et al.

CLINICAL INFECTIOUS DISEASES (2015)

Article Chemistry, Medicinal

Synthesis of novel thiazole-based 8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepines as potential antitumor and antifungal agents

Juan Ramirez et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Medicine, General & Internal

AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma

Jung-Hee Kwon et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2015)

Article Chemistry, Medicinal

Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones

Neda Adibpour et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)

Review Chemistry, Multidisciplinary

Overview of the Chemistry of 2-Thiazolines

Annie-Claude Gaumont et al.

CHEMICAL REVIEWS (2009)

Article Biochemistry & Molecular Biology

A novel approach to cyclin-dependent kinase 5/p25 inhibitors: A potential treatment for Alzheimer's disease

Mahendra Ramesh Shiradkar et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Syntheses and evaluation of antioxidant activity of sydnonyl substituted thiazolidinone and thiazoline derivatives

MH Shih et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2004)

Article Chemistry, Medicinal

Spiro[pyrrolidine-2,2′-adamantanes]:: Synthesis, anti-influenza virus activity and conformational properties

I Stylianakis et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)

Review Pharmacology & Pharmacy

Cefdinir: An advanced-generation, broad-spectrum oral cephalosporin

DRP Guay

CLINICAL THERAPEUTICS (2002)

Review Biochemistry & Molecular Biology

A review of cancer chemopreventive agents

MS Levi et al.

CURRENT MEDICINAL CHEMISTRY (2001)

Article Chemistry, Medicinal

Synthesis of some thiazolyl-pyrazoline derivatives and preliminary investigation of their hypotensive activity

G Turan-Zitouni et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2000)