4.4 Review

T Lymphocytes in Parkinson's Disease

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

CD4+T-CellTranscription Factors in IdiopathicREMSleep Behavior Disorder and Parkinson's Disease

Erika De Francesco et al.

Summary: The study revealed a distinct molecular signature in CD4+ T cells of idiopathic rapid eye movement sleep behavior disorder subjects, resembling cells from PD patients, suggesting early involvement of peripheral immunity in PD.

MOVEMENT DISORDERS (2021)

Article Immunology

Dopamine receptor D2 on CD4+ T cells is protective against neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease

Zhan Liu et al.

Summary: Research suggests that neuroinflammation driven by CD4(+) T cells in Parkinson's disease is associated with the role of dopamine receptor DRD2. In mouse models, it was found that the expression of DRD2 in CD4(+) T cells has a protective effect against neuroinflammation and neurodegeneration in PD.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Article Neurosciences

Expression of Transcription Factors in CD4+T Cells as Potential Biomarkers of Motor Complications in Parkinson's Disease

Elena Contaldi et al.

Summary: The study analyzed transcription factor genes in CD4 + T cells of Parkinson's disease patients with and without motor complications, revealing different molecular signatures. STAT1 and NR4A2 were identified as feasible biomarkers for discriminating patients with and without motor complications, while STAT6 was able to detect patients with motor complications.

JOURNAL OF PARKINSONS DISEASE (2021)

Article Immunology

T lymphocyte senescence is attenuated in Parkinson's disease

Antonina Kouli et al.

Summary: In this study, T cell immunosenescence was characterized in newly diagnosed PD patients, revealing reduced numbers of CD8(+) TEMRA T cells and lower expression of p16(INK4a) in CD8(+) lymphocytes compared to controls. Chronic latent CMV infection was associated with increased senescent CD8(+) lymphocytes in healthy controls, but less pronounced in PD patients, suggesting a reduction in CD8(+) T cell replicative senescence in early stages of Parkinson's disease.

JOURNAL OF NEUROINFLAMMATION (2021)

Article Immunology

T-cell dysregulation is associated with disease severity in Parkinson's Disease

Divisha Bhatia et al.

Summary: The dysregulation of peripheral immunity in Parkinson's Disease leads to a decrease in T-cell numbers, particularly CD8(+) cytotoxic T cells, and an upregulation of inflammatory genes, which are associated with disease severity. Additionally, PD T cells show increased activation upon stimulation, correlating with disease severity.

JOURNAL OF NEUROINFLAMMATION (2021)

Article Clinical Neurology

CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson's disease

Gregory P. Williams et al.

Summary: Alpha-synuclein is implicated in the activation of the immune system in Parkinson's disease, leading to T cell responses and infiltration into the CNS. Genetic deletion or using immunosuppressive drugs can reduce these damaging T cell responses, suggesting a potential avenue for disease-modifying treatments targeting the immune activation associated with alpha-synuclein pathology.

BRAIN (2021)

Article Geriatrics & Gerontology

Evidence for Peripheral Immune Activation in Parkinson's Disease

Xueping Chen et al.

Summary: Evidence suggests enhanced immune activation in the peripheral system in Parkinson's disease, with dynamic alterations in CD4+ T cell percentage and IgG level indicating an active role for peripheral immunity in disease progression, especially in female patients.

FRONTIERS IN AGING NEUROSCIENCE (2021)

Article Medicine, General & Internal

Safety, tolerability, and immune-biomarker profiling for year-long sargramostim treatment of Parkinson's disease

Katherine E. Olson et al.

Summary: The study showed that long-term treatment with 3 micrograms/kilogram/day of sargramostim significantly reduced the number and severity of adverse events, while improving immune function and alleviating Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale scores. This dosage regimen is effective and well-tolerated for restoring immune homeostasis.

EBIOMEDICINE (2021)

Article Neurosciences

Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson's disease

Aaron D. Thome et al.

Summary: In this study, a shift towards a pro-inflammatory peripheral immune response in patients with Parkinson's disease (PD) was identified, with the loss of suppressive functions of regulatory T cells (Tregs) being a significant contributing factor. Ex vivo expansion of Tregs restored and enhanced their suppressive functions, suggesting a potential cell therapeutic approach for patients with PD.

NPJ PARKINSONS DISEASE (2021)

Article Medicine, Research & Experimental

Increased Tc17 cell levels and imbalance of naive/effector immune response in Parkinson's disease patients in a two-year follow-up: a case control study

Diana D. Alvarez-Luquin et al.

Summary: The study found that untreated PD patients showed changes in immune cell populations after 2 years, exhibiting an imbalance in naive/effector immune response. Levels of naive and effector cells were associated with clinical deterioration and aging. Higher Tc17 levels suggest increased inflammatory response that may impact disease progression.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

Article Immunology

Altered Actinobacteria and Firmicutes Phylum Associated Epitopes in Patients With Parkinson's Disease

Zhuo Li et al.

Summary: The study found significant differences in gut microbiota between Parkinson's disease (PD) patients and controls, which were associated with abnormal inflammatory indicators, providing insights into the pathogenesis of the disease.

FRONTIERS IN IMMUNOLOGY (2021)

Review Clinical Neurology

The Pathogenesis of Parkinson's Disease: A Complex Interplay Between Astrocytes, Microglia, and T Lymphocytes?

Adina N. MacMahon Copas et al.

Summary: Parkinson's disease is a neurodegenerative disorder characterized by both motor and non-motor symptoms, including neuroinflammation and degeneration of dopaminergic neurons. In addition to the role of glial cells in maintaining CNS homeostasis, recent evidence suggests that peripheral immune cells, particularly T lymphocytes, play a significant role in the pathogenesis of the disease.

FRONTIERS IN NEUROLOGY (2021)

Article Cell Biology

Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson's disease

Pingping Wang et al.

Summary: The study reveals the presence of a large population of CD8(+) T cells progressing continuously and remarkably expanded CD4 CTLs in PD patients through TCR tracking. Additionally, potential TCR-antigen pairs were identified, providing evidence for peripheral T cells to participate in neuronal degeneration.

CELL DISCOVERY (2021)

Article Clinical Neurology

Dysregulation of the Adaptive Immune System in Patients With Early-Stage Parkinson Disease

Zhaoqi Yan et al.

Summary: The study reveals alterations in CD4(+) T cells and B cells in patients with early-stage Parkinson's disease, showing a proinflammatory state and associations with clinical motor disease severity.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

Article Biochemistry & Molecular Biology

Alpha synuclein deficiency increases CD4+ T-cells pro-inflammatory profile in a Nurr1-dependent manner

Dorit Trudler et al.

JOURNAL OF NEUROCHEMISTRY (2020)

Letter Gastroenterology & Hepatology

Older patients with IBD might have higher risk of Parkinson's disease

Qian-Yi Wan et al.

Review Rheumatology

Mycophenolate mofetil, azathioprine and tacrolimus: mechanisms in rheumatology

Jasper C. A. Broen et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

Article Multidisciplinary Sciences

α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson's disease

Cecilia S. Lindestam Arlehamn et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Bystander CD4+T cells: crossroads between innate and adaptive immunity

Hong-Gyun Lee et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Review Gastroenterology & Hepatology

The risk of Parkinson's disease in inflammatory bowel disease: A systematic review and meta-analysis

Feng Zhu et al.

DIGESTIVE AND LIVER DISEASE (2019)

Review Pharmacology & Pharmacy

Th17 cells: a promising therapeutic target for Parkinson's disease?

Iryna Prots et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2019)

Article Neurosciences

Immune system and new avenues in Parkinson's disease research and treatment

Ava Nasrolahi et al.

REVIEWS IN THE NEUROSCIENCES (2019)

Review Immunology

Deciphering targets of Th17 cells fate: From metabolism to nuclear receptors

Vinicius de Oliveira Boldrini et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2019)

Article Multidisciplinary Sciences

Intestinal infection triggers Parkinson's disease-like symptoms in Pink1-/- mice

Diana Matheoud et al.

NATURE (2019)

Review Neurosciences

Gut Inflammation in Association With Pathogenesis of Parkinson's Disease

Qian-Qian Chen et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Article Oncology

Abnormal subpopulations of peripheral blood lymphocytes are involved in Parkinson's disease

Congcong Sun et al.

ANNALS OF TRANSLATIONAL MEDICINE (2019)

Review Neurosciences

The role of regulatory T cells in nervous system pathologies

Samuel S. Duffy et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2018)

Article Neurosciences

Reduced Activated T Lymphocytes (CD4+CD25+) and Plasma Levels of Cytokines in Parkinson's Disease

Natalia Pessoa Rocha et al.

MOLECULAR NEUROBIOLOGY (2018)

Article Cell & Tissue Engineering

Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease

Annika Sommer et al.

CELL STEM CELL (2018)

Review Oncology

Immune cell subset differentiation and tissue inflammation

Pu Fang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Article Clinical Neurology

Immune Cell Activation in the Cerebrospinal Fluid of Patients With Parkinson's Disease

Jens B. Schroeder et al.

FRONTIERS IN NEUROLOGY (2018)

Article Clinical Neurology

Expanded autologous regulatory T-lymphocyte infusions in ALS A phase I, first-in-human study

Jason R. Thonhoff et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2018)

Review Immunology

TH2 cell development and function

Jennifer A. Walker et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

T cells from patients with Parkinson's disease recognize α-synuclein peptides

David Sulzer et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

Timothy R. Sampson et al.

Article Immunology

Infiltrating T lymphocytes reduce myeloid phagocytosis activity in synucleinopathy model

Annika Sommer et al.

JOURNAL OF NEUROINFLAMMATION (2016)

Article Multidisciplinary Sciences

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

Carolina Cebrian et al.

NATURE COMMUNICATIONS (2014)

Article Immunology

Mitochondrial and cytosolic roles of PINK1 shape induced regulatory T-cell development and function

Gavin I. Ellis et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2013)

Review Biotechnology & Applied Microbiology

Immunotherapy of allergic diseases using probiotics or recombinant probiotics

M. S. P. de Azevedo et al.

JOURNAL OF APPLIED MICROBIOLOGY (2013)

Article Neurosciences

CD4+Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson's Disease

Jessica A. Hutter Saunders et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2012)

Article Clinical Neurology

Human leukocyte antigen variation and Parkinson's disease

Andreas Puschmann et al.

PARKINSONISM & RELATED DISORDERS (2011)

Article Cell Biology

Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease

Ashley D. Reynolds et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

Article Clinical Neurology

Blood-brain barrier dysfunction in Parkinsonian midbrain in vivo

R Kortekaas et al.

ANNALS OF NEUROLOGY (2005)

Article Clinical Neurology

Alterations of T-lymphocyte populations in Parkinson disease

Y Baba et al.

PARKINSONISM & RELATED DISORDERS (2005)