Pronounced Orthostatic Hypotension in GBA-Related Parkinson's Disease

Patients with Parkinson's disease (PD) carrying variants in the Glucocerebrosidase (GBA) gene (GBA-PD) suffer from orthostatic symptoms more frequently than idiopathic PD patients (IPD). Systematic measurements of the blood pressure have not yet been performed. In the present study, a prospective analysis of 33 GBA-PD and 313 IPD patients was carried out. Systolic blood pressure upon changing from the supine to the upright position dropped more strongly in GBA-PD compared to IPD patients. Diastolic blood pressure and heart rate did not differ between groups. This study provides further evidence for a pronounced involvement of the autonomic nervous system in GBA-PD.

Automated summary

This study found that PD patients carrying variants in the GBA gene are more likely to experience orthostatic symptoms compared to IPD patients. The drop in systolic blood pressure during posture changes suggests a close involvement of the autonomic nervous system in GBA-PD.