Decreased Cerebral Blood Flow and Delayed Arterial Transit Are Independently Associated With White Matter Hyperintensity

AimWhite matter hyperintensities (WMH) and lacunes were important features of cerebral small vessel disease (CSVD), which contributes to 25% of ischemic strokes and 45% of dementias. Currently, the underlying mechanisms of WMH and lacunes are not clear, and the role of hemodynamic changes is not fully investigated. In this study, we aimed to measure the cerebral blood flow (CBF) and arterial transit in CSVD patients and to investigate their association with WMH and lacunes. MethodsWe retrospectively analyzed the prospectively collected database of CSVD patients. Ninety-two CSVD patients with complete imaging data were included. We used arterial spin labeling (ASL) with post-labeling delay time (PLD) of 1,525 ms and 2,025 ms to measure CBF respectively, and the difference between CBFPLD1.5 and CBFPLD2.0 was recorded as delta CBF. We performed regression analysis to understand the contribution of CBF, delta CBF to CSVD imaging markers. ResultsWe found that CBF derived from both PLDs was associated with WMH volume and the presence of lacune. CBFPLD1.5 was significantly lower than CBFPLD2.0 in CSVD patients, and delta CBF was correlated with WMH volume but not the presence of lacune. Furthermore, CBFPLD2.0 and delta CBF were both associated with WMH in multiple regression analyses, suggesting an independent effect of delayed arterial transit. On an exploratory basis, we also investigated the relationship between venous disruption on delta CBF, and we found that delta CBF correlated with deep medullary veins score. ConclusionBoth CBF and arterial transit were associated with WMH. ASL with multiple PLDs could provide additional hemodynamic information to CSVD-related studies.

Automated summary

This study investigated the association between cerebral blood flow (CBF) and arterial transit with white matter hyperintensities (WMH) and lacunes in patients with cerebral small vessel disease (CSVD). The results showed that both CBF derived from two post-labeling delay times (PLDs) were associated with WMH volume and the presence of lacune. Additionally, delta CBF was correlated with WMH volume but not the presence of lacune. This suggests that delayed arterial transit has an independent effect on WMH.