4.5 Article

Label-Free Sensing of Cysteine through Cadmium Ion Coordination: Smartphone-Based Electrochemical Detection

Journal

CHEMPLUSCHEM
Volume 87, Issue 3, Pages -

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.202200040

Keywords

cysteine; point-of-care testing; sensors; smartphones; square wave voltammetry

Funding

  1. National Key Research and Development Program [2018YFC1707701]
  2. National Natural Science Foundation of China [81971703, 81801793]
  3. Zhejiang Provincial Natural Science Foundation of China [LZ18C100001]
  4. China Postdoctoral Science Foundation [2018M642439, 2018M630677, 2019T120518]

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This study proposes a label-free cysteine sensor based on smartphone technology, which can be used for point-of-care testing. The sensor system shows high linearity correlation and low detection limit for cysteine. It provides an effective and portable method for cysteine detection.
The detection of biologically important compounds such as cysteine remains a challenge for monitoring body metabolism. This work proposes a transition metal ion coordination-based label-free cysteine sensor with smartphone-based square wave voltammetry sensing system for the point-of-care testing (POCT). In the sensing system, potential excitation and current measurements were accomplished by a miniaturized and integrated circuit board with a smartphone to wirelessly control the system via Bluetooth. The electrochemical currents changed with the cysteine concentrations ranging from 0 mu M to 200 mu M with a linearity correlation coefficient of 0.9915. The limit of detection was as low as 0.0149 mu M for cysteine. The smartphone-based system provides an effective strategy for cysteine detection, and it can also serve as a promising portable sensing platform for the analysis of other small molecules.

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