Journal
CELL REPORTS
Volume 39, Issue 2, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2022.110667
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Funding
- Spanish Ministry of Science, Innovation, and Universities [PGC2018-096631-B-I00]
- European Research Council [ERC-2014-CoG-647012, ERC-2013-CoG616080]
- European Union [798326]
- Agence Nationale de la Recherche [ANR-21-CE37-0010]
- European Research Council under the European Union's Horizon 2020 research and innovation program (NEUROGOAL) [677878]
- Region Nouvelle-Aquitaine
- University of Bordeaux
- INSERM
- CNRS
- Investissements d'Avenir [ANR-10-LABX-54MEMOLIFE, ANR-11-IDEX-0001-02 PSL*]
- French Ministry of Research
- Labex MemoLife
- [ANR-10-INBS-04]
- [ANR-10LABX-54MEMOLIFE]
- [ANR-11-IDEX-000-02 PSL*]
- [ANR-15-CE16-0003]
- [ANR-19-CE16-0017-02]
- Agence Nationale de la Recherche (ANR) [ANR-21-CE37-0010] Funding Source: Agence Nationale de la Recherche (ANR)
- Marie Curie Actions (MSCA) [798326] Funding Source: Marie Curie Actions (MSCA)
- European Research Council (ERC) [677878] Funding Source: European Research Council (ERC)
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This study reveals the interaction between thalamic activity and Cajal-Retzius cells (CRc) in the construction of the cortical layer 1 (L1). Thalamic activity and NMDA receptors regulate the early density of CRc, which in turn affects the distribution of upper layer interneurons and excitatory synapses, resulting in a significant impact on the activity of output pyramidal neuron dendrites.
Cortical wiring relies on guidepost cells and activity-dependent processes that are thought to act sequentially. Here, we show that the construction of layer 1 (L1), a main site of top-down integration, is regulated by crosstalk between transient Cajal-Retzius cells (CRc) and spontaneous activity of the thalamus, a main driver of bottom-up information. While activity was known to regulate CRc migration and elimination, we found that prenatal spontaneous thalamic activity and NMDA receptors selectively control CRc early density, without affecting their demise. CRc density, in turn, regulates the distribution of upper layer inter neurons and excitatory synapses, thereby drastically impairing the apical dendrite activity of output pyramidal neurons. In contrast, postnatal sensory-evoked activity had a limited impact on L1 and selectively perturbed basal dendrites synaptogenesis. Collectively, our study highlights a remarkable interplay between thalamic activity and CRc in L1 functional wiring, with major implications for our understanding of cortical development.
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