Journal
CELL REPORTS
Volume 38, Issue 11, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2022.110521
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Funding
- LabEx MemoLife (Paris, France)
- ANR Mopla
- Fondation Bettencourt Schueller [2022-A0100612385]
- Zhejiang Provincial Natural Science Foundation of China [LR19C090001]
- National Natural Science Foundation of China [31922031]
- Ecole Normale Superieure (Paris, France)
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This study reveals the presence of symmetric and asymmetric anti-Hebbian spike-timing-dependent plasticity (STDP) in the striatum, with opposite plasticity dominance and different roles in different stages and types of learning.
The striatum mediates two learning modalities: goal-directed behavior in dorsomedial (DMS) and habits in dorsolateral (DLS) striata. The synaptic bases of these learnings are still elusive. Indeed, while ample research has described DLS plasticity, little remains known about DMS plasticity and its involvement in procedural learning. Here, we find symmetric and asymmetric anti-Hebbian spike-timing-dependent plasticity (STDP) in DMS and DLS, respectively, with opposite plasticity dominance upon increasing corticostriatal activity. During motor-skill learning, plasticity is engaged in DMS and striatonigral DLS neurons only during early learning stages, whereas striatopallidal DLS neurons are mobilized only during late phases. With a mathematical modeling approach, we find that symmetric anti-Hebbian STDP favors memory flexibility, while asymmetric anti-Hebbian STDP favors memory maintenance, consistent with memory processes at play in procedural learning.
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