Journal
CELL REPORTS
Volume 39, Issue 5, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2022.110771
Keywords
-
Categories
Funding
- NIH [R01 CA179991, R35 CA220508]
- MSK Functional Genomics Initiative
- NCI Cancer Center [P30 CA08748]
- Kleberg Foundation
- Cycle for Survival
Ask authors/readers for more resources
We compared human and 12 non-human primates to identify sequence variations in known cancer genes. We found 395 human-specific fixed non-silent substitutions that emerged during human evolution. Functional analysis identified several substitutions predicted to alter protein function, including one located in the most evolutionarily conserved domain of human BRCA2.
We performed a comparative analysis of human and 12 non-human primates to identify sequence variations in known cancer genes. We identified 395 human-specific fixed non-silent substitutions that emerged during evolution of human. Using bioinformatics analyses for functional consequences, we identified a number of substitutions that are predicted to alter protein function; one of these mutations is located at the most evolutionarily conserved domain of human BRCA2.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available