4.6 Article

Non-operative management after chemoradiotherapy plus consolidation or sandwich (induction with bevacizumab and consolidation) chemotherapy in patients with locally advanced rectal cancer: a multicentre, randomised phase II trial (NOMINATE trial)

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Adding Narrow-Band Imaging to Chromoendoscopy for the Evaluation of Tumor Response to Neoadjuvant Therapy in Rectal Cancer

Mitsuaki Ishioka et al.

Summary: Despite limited improvement in diagnostic accuracy, adding narrow-band imaging to chromoendoscopy improved inter-rater agreement between expert and non-expert endoscopists. Narrowband imaging is a reliable and promising modality for standardizing the diagnosis of clinical complete response.

DISEASES OF THE COLON & RECTUM (2021)

Article Oncology

Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial

Renu R. Bahadoer et al.

Summary: The RAPIDO trial aimed to reduce systemic relapses in locally advanced rectal cancer through short-course radiotherapy, chemotherapy, and delayed surgery. Results showed a decreased probability of disease-related treatment failure in the experimental group compared to standard care, with diarrhea being the most common adverse event and neurological toxicity being prominent in the standard care group during adjuvant chemotherapy.

LANCET ONCOLOGY (2021)

Review Oncology

The efficacy and safety of adding bevacizumab in neoadjuvant therapy for locally advanced rectal cancer patients: A systematic review and meta-analysis

Yue Zhou et al.

Summary: The addition of bevacizumab in the neoadjuvant chemoradiotherapy, especially in the total neoadjuvant treatment, for locally advanced rectal cancer patients shows promising efficacy and acceptable safety. The pooled pathological complete response rate for bevacizumab-relevant cohorts was 21%, with low rates of Grade 3/4 bevacizumab-specific adverse events. However, caution should be taken in interpreting the results due to the limited amount of relevant data and further confirmation by future studies is needed.

TRANSLATIONAL ONCOLOGY (2021)

Article Oncology

Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23) : a multicentre, randomised, open-label, phase 3 trial

Thierry Conroy et al.

Summary: In patients with cT3 or cT4 M0 rectal cancer, intensifying chemotherapy with FOLFIRINOX before preoperative chemoradiotherapy significantly improved disease-free survival outcomes and reduced neurotoxicity. Thus, the PRODIGE 23 results have the potential to impact clinical practice.

LANCET ONCOLOGY (2021)

Article Oncology

Preliminary results of the organ preservation of rectal adenocarcinoma (OPRA) trial.

Julio Garcia-Aguilar et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Review Gastroenterology & Hepatology

Organ Preservation in Rectal Cancer

Jonathan B. Yuval et al.

JOURNAL OF GASTROINTESTINAL SURGERY (2020)

Article Oncology

Patient-Centered Outcomes to Decide Treatment Strategy for Patients With Low Rectal Cancer

Michitaka Honda et al.

JOURNAL OF SURGICAL ONCOLOGY (2016)