Journal
BMC PULMONARY MEDICINE
Volume 22, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12890-022-01842-1
Keywords
Respiratory syncytial virus (RSV); Infants; Toddlers; Bronchiolitis; Infection; Cohort study; Genetic susceptibility
Categories
Funding
- Clinical Leave Clinician/Scientist program of the German Center for Infection Research (DZIF) (BMBF, Bundesministerium fur Bildung und Forschung, German Ministry of Education and Research)
- Young Academy Clinician/Scientist foundation Hannover Medical School, Germany
- BMBF under the German Center for Lung Research (DZL)
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy [ExC 2155, 39087428]
- Volkswagen Stiftung within the Niedersachsische Vorab initiative
- INDIRA: Integrative Data analytIcs for Respiratory syncytial virus risk Assessment project
- iMed initiative of the Helmholtz Association
- Else Kroner-Fresenius-Foundation Forschungskolleg TITUS
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The IRIS study is an observational, multi-centre study aiming to discover host and viral factors controlling RSV disease courses in infants. It seeks to improve our understanding of the immune response against this virus and may disclose novel diagnostic and treatment approaches for respiratory infections in infants.
Background: Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory tract infection in infants. Globally, RSV is responsible for approximately 3.2 million hospital admissions and about 60,000 in-hospital deaths per year. Methods: Infection with RespIratory Syncytial Virus (IRIS) is an observational, multi-centre study enrolling infants with severe RSV infection and healthy controls. Inclusion criteria are age between 0 and 36 months and hospitalisation due to RSV infection at three German sites. Exclusion criteria are premature birth, congenital or acquired bronchopulmonary or cardiac diseases, and immunodeficiency. Healthy control probands are enrolled via recruitment of patients undergoing routine surgical procedures. Blood and respiratory specimens are collected upon admission, and RSV and other pathogens are analysed by multiplex polymerase chain reaction. Different biomaterials, including plasma, nasal lining fluid, blood cells, DNA, and RNA specimens, are sampled in a dedicated biobank. Detailed information on demographic characteristics and medical history is recorded, and comprehensive clinical data, including vital signs, medication, and interventions. Discussion: The IRIS study aims to discover host and viral factors controlling RSV disease courses in infants. The approach including multi-omics characterisation in clinically well-characterized children with RSV bronchiolitis seeks to improve our understanding of the immune response against this virus. It may disclose novel diagnostic and treatment approaches for respiratory infections in infants.
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