Journal
ANNALS OF LABORATORY MEDICINE
Volume 42, Issue 2, Pages 141-+Publisher
KOREAN SOC LABORATORY MEDICINE
DOI: 10.3343/alm.2022.42.2.141
Keywords
Key Words; Cell-free nucleic acid; Circulating tumor DNA; Pre-analytical phase; Epidermal growth factor receptor; Clinical practice guidelines
Categories
Funding
- Research Fund of Quality Control Committee, Korean Society for Laboratory Medicine [2020-01-006]
- Korean Society for Genetic Diagnostics
Ask authors/readers for more resources
Standardization of pre-analytical procedures is essential for obtaining clinically reliable results in cfDNA testing. This article provides evidence-based clinical practice guidelines for the pre-analytical phase procedures of plasma EGFR variant testing. By standardizing pre-analytical procedures, the analytical performance of cfDNA testing can be improved.
Standardization of cell-free DNA (cfDNA) testing processes is necessary to obtain clinically reliable results. The pre-analytical phase of cfDNA testing greatly influences the results because of the low proportion and stability of circulating tumor DNA (ctDNA). In this re-view, we provide evidence-based clinical practice guidelines for pre-analytical phase pro-cedures of plasma epidermal growth factor receptor gene (EGFR) variant testing. Specific recommendations for pre-analytical procedures were proposed based on evidence from the literature and our experimental data. Standardization of pre-analytical procedures can improve the analytical performance of cfDNA testing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available