Journal
ANNALS OF LABORATORY MEDICINE
Volume 42, Issue 3, Pages 299-305Publisher
KOREAN SOC LABORATORY MEDICINE
DOI: 10.3343/alm.2022.42.3.299
Keywords
Myelodysplastic syndrome; Bone marrow fibrosis; International prognostic scoring system; Allogeneic stem cell transplantation; Key Words
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In this review, the available literature on the presentation and prognosis of patients with MDS and concurrent BMF is discussed, highlighting the importance of considering BMF in treatment decisions. The prognostic impact of BMF should be taken into account when deciding on transplantation, especially for intermediate-risk patients.
Myelodysplastic syndrome (MDS) is a diverse hematological malignancy with a wide spectrum of presentations and implications. Treatment strategies for patients with MDS heavily rely on prognostic scoring systems, such as the revised international prognostic scoring system (IPSS-R). Bone marrow fibrosis (BMF) has been identified as an independent risk factor for poor survival in patients with MDS, irrespective of the IPSS-R risk category. However, BMF is not widely included in scoring systems and is not always considered by clinicians when making treatment decisions for patients. In this review, we discuss the available literature about the presentation and prognosis of patients with MDS and concurrent BMF. The prognostic impact of BMF should be factored in when deciding on transplant candidacy, especially for intermediate-risk patients.
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