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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
A Garami et al.
MOLECULAR CELL (2003)
The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation
HS Yang et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation
M Stolovich et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin
CC Hudson et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
DR Bolster et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-Kinase/Akt pathway
BD Manning et al.
MOLECULAR CELL (2002)
Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin and is independent of S6K1 and rpS6 phosphorylation
H Tang et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Phosphatidic acid-mediated mitogenic activation of mTOR signaling
YM Fang et al.
SCIENCE (2001)
Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase
XM Wang et al.
EMBO JOURNAL (2001)
Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex
KF Wilson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
MY El-Mir et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)