Journal
CANCER LETTERS
Volume 360, Issue 2, Pages 106-113Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2015.02.009
Keywords
Methylation; Histone; Tumor suppressor genes; Autophagy; Cancer
Categories
Funding
- National Natural Science Foundation of China [81301891]
- Zhejiang Provincial Natural Science Foundation of China [LQ13H160008]
- Zhengshu Medical Elite Scholarship Fund
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Epigenetic modifications have been considered as hallmarks of cancer and play an important role in tumor initiation and development. Epigenetic mechanisms, including DNA methylation, histone modifications, and microRNAs, may regulate cell cycle and apoptosis, as well as macroautophagy (hereafter referred to as autophagy). Autophagy, as a crucial cellular homeostatic mechanism, performs a dual role, having pro-survival or pro-death properties. A variety of signaling pathways including epigenetic control have been implicated in the upregulation or downregulation of autophagy. However, the role of epigenetic regulation in autophagy is still less well acknowledged. Recent studies have linked epigenetic control to the autophagic process. Some epigenetic modifiers are also involved in the regulation of autophagy and potentiate the efficacy of traditional therapeutics. Thus, understanding the novel functions of epigenetic control in autophagy may allow us to develop potential therapeutic approaches for cancer treatment. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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