Journal
JOURNAL OF AUTOIMMUNITY
Volume 74, Issue -, Pages 139-160Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2016.07.001
Keywords
Systemic lupus erythematosus; Anaemia; Leukopaenia; Thrombocytopaenia
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Haematological manifestations in systemic lupus erythematosus (SLE) are frequently observed. They are diverse and range from mild to severe. Therefore, different treatment approaches are needed from simply keeping vigilant to significant immunosuppression. Most treatment evidence is based on case reports or small retrospective studies, as few randomized controlled trials have been performed. The development of biological therapy has opened new possible ways to treat the most severe cases but further clinical trials are necessary. In this review we consider the most common and characteristic haematological manifestations of SLE patients, focusing on their pathogenesis and management. (C) 2016 Published by Elsevier Ltd.
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