4.7 Article

Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Dynamical Analysis of a Boolean Network Model of the Oncogene Role of lncRNA ANRIL and lncRNA UFC1 in Non-Small Cell Lung Cancer

Shantanu Gupta et al.

Summary: This study investigated the role of long non-coding RNAs in non-small cell lung cancer (NSCLC). Using a Boolean model, the authors identified ANRIL and UFC1 as important gene regulators in NSCLC and confirmed the significance of the miR-34a/Myc pathway in lung cancer cells.

BIOMOLECULES (2022)

Review Biochemistry & Molecular Biology

Epigenetic Mechanisms in DNA Double Strand Break Repair: A Clinical Review

Alejandra Fernandez et al.

Summary: Upon DNA damage induction, chromatin unwinds to allow repair enzymes access. Epigenetic modifications regulate this process and inhibitors of histone deacetylases and DNA methyltransferases play crucial roles in repairing double strand breaks, showing promise in cancer therapy.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Review Biochemistry & Molecular Biology

The Emerging Roles of Autophagy-Related MicroRNAs in Cancer

Chan Shan et al.

Summary: Autophagy is a crucial process in maintaining cell homeostasis and abnormal autophagy is associated with various diseases, including cancer. MicroRNAs (miRNAs) regulate gene expression and play important roles in fundamental biological processes like autophagy. Studying autophagy-related miRNAs in cancer can offer insights into cancer biology and support the development of novel anti-cancer strategies.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Multidisciplinary Sciences

Re-epithelialization and immune cell behaviour in an ex vivo human skin model

Ana Rakita et al.

SCIENTIFIC REPORTS (2020)

Review Chemistry, Medicinal

Targeting mTOR for fighting diseases: A revisited review of mTOR inhibitors

Tian Xu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Dysregulation of hsa-miR-34a and hsa-miR-449a leads to overexpression of PACS-1 and loss of DNA damage response (DDR) in cervical cancer

Mysore S. Veena et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

Systems biology approach suggests new miRNAs as phenotypic stability factors in the epithelial-mesenchymal transition

Daner A. Silveira et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2020)

Article Mathematics, Interdisciplinary Applications

p53/E2F1/miR-25 axis regulates apoptosis induction in glioblastoma cells: a qualitative model

Daner A. Silveira et al.

JOURNAL OF PHYSICS-COMPLEXITY (2020)

Review Oncology

MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer

Lu Zhang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Review Cell Biology

The multiple mechanisms that regulate p53 activity and cell fate

Antonina Hafner et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Physiology

Logical Modeling and Analysis of Cellular Regulatory Networks With GINsim 3.0

Aurelien Naldi et al.

FRONTIERS IN PHYSIOLOGY (2018)

Article Physiology

Estimating Attractor Reachability in Asynchronous Logical Models

Nuno D. Mendes et al.

FRONTIERS IN PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

The BioGRID interaction database: 2017 update

Andrew Chatr-aryamontri et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Cell Biology

Autophagy induction reduces telomerase activity in HeLa cells

Fatemeh Taji et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2017)

Review Cell Biology

Alternative mechanisms of miR-34a regulation in cancer

Eva Slabakova et al.

CELL DEATH & DISEASE (2017)

Review Oncology

miR-449a: a potential therapeutic agent for cancer

He Yong-Ming et al.

ANTI-CANCER DRUGS (2017)

Article Multidisciplinary Sciences

miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage

David W. Salzman et al.

NATURE COMMUNICATIONS (2016)

Review Genetics & Heredity

Logical Modeling and Dynamical Analysis of Cellular Networks

Wassim Abou-Jaoude et al.

FRONTIERS IN GENETICS (2016)

Article Multidisciplinary Sciences

MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cells

Aihong Mao et al.

SCIENTIFIC REPORTS (2016)

Article Oncology

MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin

Nunu Huang et al.

CANCER BIOLOGY & THERAPY (2015)

Review Medicine, Research & Experimental

mTOR: a pharmacologic target for autophagy regulation

Young Chul Kim et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Review Cell Biology

MicroRNAs and DNA damage response Implications for cancer therapy

Yemin Wang et al.

CELL CYCLE (2013)

Article Cell Biology

ATM pathway is essential for ionizing radiation-induced autophagy

Nan Liang et al.

CELLULAR SIGNALLING (2013)

Review Cell Biology

Control of cell cycle transcription during G1 and S phases

Cosetta Bertoli et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Review Cell Biology

MicroRNA-449 in cell fate determination

Muriel Lize et al.

CELL CYCLE (2011)

Review Biochemistry & Molecular Biology

miR-15a and miR-16-1 in cancer: discovery, function and future perspectives

R. I. Aqeilan et al.

CELL DEATH AND DIFFERENTIATION (2010)

Review Biochemistry & Molecular Biology

The miR-34 family in cancer and apoptosis

H. Hermeking

CELL DEATH AND DIFFERENTIATION (2010)

Review Genetics & Heredity

Regulation Mechanisms and Signaling Pathways of Autophagy

Congcong He et al.

ANNUAL REVIEW OF GENETICS (2009)

Article Biochemistry & Molecular Biology

MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response

Joris Pothof et al.

EMBO JOURNAL (2009)

Article Multidisciplinary Sciences

Modulation of microRNA processing by p53

Hiroshi I. Suzuki et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest

Fang Sun et al.

FEBS LETTERS (2008)

Article Biochemistry & Molecular Biology

Wip1 phosphatase modulates ATM-dependent signaling pathways

Sathyavageeswaran Shreeram et al.

MOLECULAR CELL (2006)

Article Biochemistry & Molecular Biology

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

Diane Crighton et al.

Article Multidisciplinary Sciences

miR-15 and miR-16 induce apoptosis by targeting BCL2

A Cimmino et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study

RL Bar-Or et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Multidisciplinary Sciences

Activation of p53 in cervical carcinoma cells by small molecules

S Hietanen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)