Journal
NUTRIENTS
Volume 14, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/nu14101992
Keywords
silicon; silicon chelate; vitamin D; mechanochemistry; bone; fracture healing; bone loss; osteoporosis
Categories
Funding
- Institute of Solid State Chemistry and Mechanochemistry SB RAS [FWUS2021-0005]
- Russian Science Foundation [21-13-00046]
- Administration of the Novosibirsk Region [GR-9]
- Russian Science Foundation [21-13-00046] Funding Source: Russian Science Foundation
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This study presents findings on the biological action of a supplement containing vitamin D and soluble silicon, which are involved in bone formation and mineralization. The supplement showed the ability to stimulate bone tissue regeneration, accelerate bone cell differentiation, and promote the restoration of bone structure. Additionally, it enhanced calcium absorption and reduced skeletal damage.
This study presents findings on the biological action of an integrated supplement containing the following components involved in osteogenesis and mineralization: vitamin D and silicon in the bioavailable and soluble form. A hypothesis that these components potentiate one another's action and make calcium absorption by the body more efficient was tested. Biological tests of the effect of vitamin D and silicon chelates on bone fracture healing and bone turnover were conducted using ICR mice and albino Wistar rats. Radiographic and biochemical studies show that the supplement simultaneously containing silicon chelates and vitamin D stimulates bone tissue regeneration upon mechanical defects and accelerates differentiation of osteogenic cells, regeneration of spongy and compact bones, and restoration of bone structure due to activation of osteoblast performance. Bone structure restoration was accompanied by less damage to skeletal bones, apparently due to better absorption of calcium from food. The studied supplement has a similar effect when used to manage physiologically induced decalcification, thus holding potential for the treatment of osteomalacia during pregnancy or occupational diseases (e.g., for managing bone decalcification in astronauts).
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