4.7 Article

Antilipidemic and Hepatoprotective Effects of Ethanol Extract of Justicia spicigera in Streptozotocin Diabetic Rats

Journal

NUTRIENTS
Volume 14, Issue 9, Pages -

Publisher

MDPI
DOI: 10.3390/nu14091946

Keywords

antioxidant; bioactive compounds; diabetes; Justicia spicigera; liver; streptozotocin

Funding

  1. Coordinacion de Investigacion Cientifica (UMSNH) [2.16]
  2. UNAM-DGAPA-PAPIIT [IN218819, IN219022]

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EJS has the potential to reduce blood glucose levels and weight, improve lipid profile and liver function, and inhibit oxidative stress in rats with streptozotocin-induced diabetes.
Oxidative stress is a factor that contributes to the development of complications in diabetes; however, its effects can be counteracted using exogenous antioxidants that are found in some plants, which is why people turn to traditional medicines in the search for therapeutic treatment. Justicia spicigera has been demonstrated to have the capacity to reduce glycemic levels; however, its effects on non-insulin-dependent organs such as the liver have not been reported. During 30 days of administration of Justicia spicigera ethanol extract, the blood glucose and weight of rats were measured every 5 days. Once the treatment was concluded, the rats were sacrificed. Corporal weight, blood glucose, cholesterol, very-low-density lipoprotein (VLDL), triglycerides, total lipids, and liver profile were reduced in the diabetic condition and normalized with the application of ethanol extract from J. spicigera (EJS). Additionally, there was a significant increase in catalase and superoxide dismutase activity in the control diabetic rats, a decrease in their activity with the extract administration, and no effect on normoglycemic rats. In conclusion, EJS is considered to be capable of reducing oxidative stress by maintaining diminished lipid and liver function profiles in male Wistar rats with streptozotocin-induced diabetes.

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