Journal
NUTRIENTS
Volume 14, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/nu14051049
Keywords
gummy probiotic; L; plantarum Dad-13; moderate undernutrition; gut microbiota modulation; Short-Chain Fatty Acid
Categories
Funding
- Ministry of Research and Technology/National Research and Innovation Agency of Republic Indonesia (RISTEK-BRIN) [3189/UN1.DITLIT/DITLIT/PT/2020]
- PUI PT-Centre of Excellence for Probiotics [1230/E3/SPPK/2020]
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This study evaluated the efficacy of L. plantarum Dad-13 in preventing the progression of severe undernutrition. The results showed that the probiotic group had better improvements in anthropometry and nutritional status. L. plantarum Dad-13 also modulated the gut microbiota, increasing the number of butyric acid-producing bacteria and inhibiting the growth of Enterobacteriaceae. This gut modulation was associated with an increase in short-chain fatty acids, especially total SCFA, propionic, and butyric acid.
Undernutrition is associated with gut microbiota unbalance, and probiotics are believed to restore it and improve gut integrity. A randomized double-blind controlled trial was conducted to evaluate the efficacy of gummy L. plantarum Dad-13 (10(8-9) CFU/3 g) to prevent the progression of severe undernutrition. Two groups of moderate undernutrition infants were involved in this study, namely the placebo (n = 15) and probiotics (n = 15) groups, and were required to consume the product for 50 days. 16S rRNA sequencing and qPCR were used for gut microbiota analysis, and gas chromatography was used to analyze Short-Chain Fatty Acid (SCFA). The daily food intake of both groups was recorded using food records. Our results revealed that the probiotic group had better improvements regarding the anthropometry and nutritional status. In addition, L. plantarum Dad-13 modulated the butyric acid-producing bacteria to increase and inhibit the growth of Enterobacteriaceae. This gut modulation was associated with the increment in SCFA, especially total SCFA, propionic, and butyric acid. The number of L. plantarum was increased after the probiotic intervention. However, L. plantarum Dad-13 was not able to change the alpha and beta diversity. Therefore, L. plantarum Dad-13 has been proven to promote the growth of beneficial bacteria.
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