4.7 Article

The Prevention Role of Theaflavin-3,3′-digallate in Angiotensin II Induced Pathological Cardiac Hypertrophy via CaN-NFAT Signal Pathway

Journal

NUTRIENTS
Volume 14, Issue 7, Pages -

Publisher

MDPI
DOI: 10.3390/nu14071391

Keywords

theaflavin-3, 3 '-digallate; pathological cardiac hypertrophy; oxidative stress; calcium ion; calcineurin; nuclear factor of activated T cells

Funding

  1. Platform Construction Project of Chinese White Tea Science and Technology Correspondent, China [2020L3031]
  2. Science and Technology Innovation Platform Project of Fujian Provincial Department of Science and Technology, China [2018N2004]

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Theaflavin-3,3'-digallate (TF3), a compound found in black tea, has been found to have anti-coronary heart disease effect. In this study, TF3 was shown to reduce cell size and fetal gene mRNA level in a heart failure cell model, potentially preventing pathological cardiac hypertrophy. TF3 may be a promising natural compound for the treatment of heart failure.
Theaflavin-3,3'-digallate (TF3) is a representative theaflavin of black tea and is remarkable for the anti-coronary heart disease effect. As an adaptive response to heart failure, pathological cardiac hypertrophy (PCH) has attracted great interest. In this study, the PCH cell model was established with H9c2 cells by angiotensin II, and the prevention effect and mechanisms of TF3 were investigated. The results showed that the cell size and fetal gene mRNA level were significantly reduced as pretreated with TF3 at the concentration range of 1-10 mu M, also the balance of the redox system was recovered by TF3 at the concentration of 10 mu M. The intracellular Ca2+ level decreased, Calcineurin (CaN) expression was down-regulated and the p-NFATc3 expression was up-regulated. These results indicated that TF3 could inhibit the activation of the CaN-NFAT signal pathway to prevent PCH, and TF3 may be a potentially effective natural compound for PCH and heart failure.

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