Journal
NUTRIENTS
Volume 14, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/nu14091747
Keywords
ginseng berry extract; sarcopenic obesity; PI3K; Akt pathway; protein synthesis; degradation; inflammation
Categories
Ask authors/readers for more resources
Sarcopenic obesity, a combined state of sarcopenia and obesity, is a serious health problem related to metabolic diseases. A study found that Panax ginseng berry extract (GBE) can attenuate both obesity and sarcopenia by activating the PI3K/Akt pathway, which regulates muscle synthesis and degradation.
Sarcopenia and obesity are serious health problems that are highly related to several metabolic diseases. Sarcopenic obesity, a combined state of sarcopenia and obesity, results in higher risks of metabolic diseases and even mortality than sarcopenia or obesity alone. Therefore, the development of therapeutic agents for sarcopenic obesity is crucial. C57BL/6 mice were fed with a high-fat diet (HFD) for 9 weeks. Then, mice were administered with Panax ginseng berry extract (GBE) for an additional 4 weeks, with continuous HFD intake. GBE significantly decreased the food efficiency ratio, serum lipid and insulin levels, adipose tissue weights, and adipocyte size. It significantly increased the grip strength, muscle masses, and myofiber cross-sectional area. It deactivated the protein kinase C (PKC) theta and zeta, resulting in activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway, which is known to regulate muscle synthesis and degradation. Furthermore, it inhibited the production of inflammatory cytokines in the muscle tissue. GBE attenuated both obesity and sarcopenia. Thus, GBE is a potential agent to prevent or treat sarcopenic obesity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available