Phenotypes and Endotypes of Peach Allergy: What Is New?

Peach allergy is emerging as a common type of fresh-fruit allergy in Europe, especially in the Mediterranean area. The clinical manifestations of peach allergy tend to have a peculiar geographical distribution and can range from mild oral symptoms to anaphylaxis, depending on the allergic sensitization profile. The peach allergen Pru p 7, also known as peamaclein, has recently been identified as a marker of peach allergy severity and as being responsible for peculiar clinical features in areas with high exposure to cypress pollen. This review addresses the latest findings on molecular allergens for the diagnosis of peach allergy, the clinical phenotypes and endotypes of peach allergy in adults and children, and management strategies, including immunotherapy, for peach allergy.

Automated summary

Peach allergy is becoming a common type of fresh-fruit allergy in Europe, particularly in the Mediterranean area. The severity of clinical symptoms varies depending on allergic sensitization profile, ranging from mild oral symptoms to anaphylaxis. The peach allergen Pru p 7 has been identified as a marker of peach allergy severity, particularly in areas with high exposure to cypress pollen. This review discusses the latest findings on molecular allergens, clinical phenotypes, and management strategies for peach allergy.