Journal
NUTRIENTS
Volume 14, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/nu14081649
Keywords
polycystic ovary syndrome; PCOS; vitamin D; vitamin D deficiency; vitamin D supplementation; female fertility; male fertility; in vitro fertilization; pregnancy; reproductive health
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Funding
- Semmelweis Science and Innovation Fund [STIA-OTKA-2021]
- Hungarian Hypertension Society
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Vitamin D deficiency is common in PCOS patients and is correlated with the severity of the condition. Vitamin D supplementation can improve fertility and IVF indicators and reduce the risk of pregnancy-related complications for both mothers and fetuses.
Polycystic ovary syndrome (PCOS) is one of the most common endocrine reproductive disorders in women. Vitamin D deficiency is also quite common in this condition. The degree of vitamin D deficiency correlates with the severity of PCOS. Both male and female vitamin D levels play a role in fertility and affect the outcomes of in vitro fertilization (IVF). Moreover, fertility and IVF indicators are improved by vitamin D not only in healthy women but in those diagnosed with PCOS. Both vitamin D deficiency and PCOS increase pregnancy-related complications. Vitamin D supplementation and optimal vitamin D levels decrease both maternal and fetal risk for complications and adverse events. Furthermore, vitamin D supplementation may ameliorate or even prevent pregnancy-related reversible bone loss in mothers. This review emphasizes the roles of vitamin D deficiency and vitamin D supplementation and their correlation with PCOS regarding reproductive health.
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